Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | SCN1A | P35498 | 2/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963488 | 0.93 | PHLPP2 (0.83) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL14924442 | 0.90 | GAA (0.74) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL8639938 | 0.86 | PHLPP2 (0.73) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL8963375 | 0.86 | PHLPP2 (0.73) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL14947119 | 0.85 | PHLPP2 (0.54) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL206554 | 0.85 | TDP1 (0.61) | ALDH1A1MAPTGAALMNAMAOA | |
| SCHEMBL10777193 | 0.84 | PHLPP2 (0.71) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL1701017 | 0.84 | PHLPP2 (0.71) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL8487897 | 0.84 | PHLPP2 (0.71) | PHLPP2ALDH1A1MAPTGAALMNA | |
| SCHEMBL4835480 | 0.84 | PHLPP2 (1.00) | PHLPP2ALDH1A1MAPTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071367-A1 | METHODS OF TREATING COGNITIVE IMPAIRMENTS OR DYSFUNCTION | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2018-03-15 | — | — | US | disclosed |
| US-20170281732-A1 | METHODS OF TREATING MILD BRAIN INJURY | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2017-10-05 | — | — | US | disclosed |
| US-20170281732-A1 | METHODS OF TREATING MILD BRAIN INJURY | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2017-10-05 | — | — | US | disclosed |
| US-20170266257-A1 | METHODS OF TREATING TRAUMATIC BRAIN INJURY | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170121385-A1 | METHODS OF TREATING NEURODEGENERATIVE CONDITIONS | OXEIA BIOPHARMACEUTICALS, INC. (US) | 2017-05-04 | — | — | US | disclosed |
| US-8153660-B2 | Piperidyl-propane-thiol CCR3 modulators | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-10 | — | — | US | disclosed |
| US-20100317634-A1 | PIPERIDYL-PROPANE-THIOL CCR3 MODULATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-16 | — | — | US | disclosed |
| US-20080234283-A1 | Glutathione peroxidase mimetics for treatment of neurodegenerative, pulmonary and inflammatory diseases | RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES (IL) | 2008-09-25 | — | — | US | disclosed |
| US-20080213785-A1 | Method of predicting a benefit of antioxidant therapy for prevention or treatment of vasclar disease in hyperglycemic individuals | BBDX, INC. | 2008-09-04 | — | — | US | disclosed |
| US-20080207679-A1 | Glutathione peroxidase mimetics for the treatment of dermatoses | BERKOWITZ NOAH | 2008-08-28 | — | — | US | disclosed |
| WO-2008100629-A2 | GLUTATHIONE PEROXIDASE MIMETICS FOR THE TREATMENT OF DERMATOSES | SYNVISTA THERAPEUTICS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| US-5863913-A | ALLEVIATION OF RENAL DYSFUNCTION WITHOUT AFFECTING BLOOD PRESSURE AT A LOW BLOOD CONCENTRATION. | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1999-01-26 | — | — | US | disclosed |
| EP-0002625-B1 | PHOTOCURABLE COMPOSITIONS, PHOTOACTIVATOR- PHOTOINITIATOR COMBINATIONS USEFUL THEREIN AND METHOD OF MAKING CURED PLASTICS COMPOSITIONS THEREFROM | WARD BLENKINSOP AND COMPANY LIMITED (GB) | 1982-05-12 | — | — | EP | disclosed |
| EP-0002625-A1 | Photocurable compositions, photoactivator- photoinitiator combinations useful therein and method of making cured plastics compositions therefrom | WARD BLENKINSOP AND COMPANY LIMITED (GB) | 1979-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170266257-A1 | METHODS OF TREATING TRAUMATIC BRAIN INJURY | ATP6V1B2, FABP7, GHSR | PHLPP2 642/4885ALDH1A1 4000/4885MAPT 1278/4885 |
| US-20080234283-A1 | Glutathione peroxidase mimetics for treatment of neurodegenerative, pulmonary and inflammatory diseases | GPX1, GPX4, MPO | PHLPP2 1131/4885ALDH1A1 1010/4885MAPT 461/4885 |
| US-20100317634-A1 | PIPERIDYL-PROPANE-THIOL CCR3 MODULATORS | CCR3, CCR1, CCRL2 | PHLPP2 1272/4885ALDH1A1 583/4885MAPT 3205/4885 |
| US-20080207679-A1 | Glutathione peroxidase mimetics for the treatment of dermatoses | GPX1, GPX4, GGT1 | PHLPP2 791/4885ALDH1A1 408/4885MAPT 3190/4885 |
| US-20170121385-A1 | METHODS OF TREATING NEURODEGENERATIVE CONDITIONS | HTT, SNCA, NLN | PHLPP2 766/4885ALDH1A1 3893/4885MAPT 31/4885 |
| US-20180071367-A1 | METHODS OF TREATING COGNITIVE IMPAIRMENTS OR DYSFUNCTION | CRH, PYGB, CHAT | PHLPP2 548/4885ALDH1A1 4652/4885MAPT 354/4885 |
| US-20170281732-A1 | METHODS OF TREATING MILD BRAIN INJURY | ATP6V1B2, GHSR, CRH | PHLPP2 505/4885ALDH1A1 3892/4885MAPT 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.