SCHEMBL1125310

SCHEMBL1125310

O=Cc1cccc(C(F)(F)F)c1O

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 10/20 0.57
TLR2 O60603 1/20 0.47
TLR1 Q15399 1/20 0.47
TLR6 Q9Y2C9 1/20 0.47
NFKB1 P19838 1/20 0.46
TRIM24 O15164 1/20 0.43
TRIM33 Q9UPN9 1/20 0.43
PIM1 P11309 1/20 0.42
PIM3 Q86V86 1/20 0.42
P4HB P07237 1/20 0.41
MAOB P27338 1/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
THRB P10828 1/20 0.41
BLM P54132 1/20 0.41
KMT2A Q03164 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ALOX12 P18054 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30843799 1.00 ERN1 (0.57) ERN1TLR2TLR1TLR6NFKB1
SCHEMBL29280862 0.88 ERN1 (0.46) ERN1TLR2TLR1TLR6NFKB1
SCHEMBL31587806 0.80 ALOX12 (0.62) ERN1TLR2TLR1TLR6TRIM24
SCHEMBL173039 0.80 ALOX12 (0.62) ERN1TLR2TLR1TLR6TRIM24
SCHEMBL7031301 0.80 NFKB1 (0.42) ERN1NFKB1P4HBMAOBABCG2
SCHEMBL6853771 0.79 NFKB1 (0.44) ERN1NFKB1TRIM24TRIM33PIM1
SCHEMBL22083591 0.79 ERN1 (0.47) ERN1TLR2TLR1TLR6NFKB1
SCHEMBL29417728 0.79 NFKB1 (0.57) NFKB1TRIM24TRIM33PIM1PIM3
SCHEMBL67207 0.79 NFKB1 (0.57) NFKB1TRIM24TRIM33PIM1PIM3
SCHEMBL396017 0.78 CA2 (0.55) NFKB1MEN1LMNAKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119661416-A Small molecular probe and preparation method and application thereof 上海师范大学 2025-03-21 CN claimed
CN-119639391-A High-viscosity waterproof polyacrylate emulsion pressure-sensitive adhesive and preparation method and application thereof 山东佳润新材料有限公司 2025-03-18 CN claimed
CN-117820164-A Bis 3- (trifluoromethyl) salicylaldehyde 1, 4-xylylenediamine Schiff base, and preparation method and application thereof 安徽省东超科技有限公司 2024-04-05 CN claimed
EP-2970267-B3 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-05-30 EP claimed
CN-122080106-A Oleanolic acid acylhydrazone derivative and preparation method and application thereof 2026-05-26 CN disclosed
EP-4703358-A1 BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF China Pharmaceutical University (CN) 2026-03-04 EP disclosed
CN-121592119-A Solid luminescent material, preparation method and application thereof 安徽省东超科技有限公司 2026-03-03 CN disclosed
US-20250382312-A1 BORON CONTAINING PYRAZOLE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF BORAH INC (US) 2025-12-18 US disclosed
EP-4370207-B1 BICYCLIC COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS NIDO BIOSCIENCES INC (US) 2025-12-17 EP disclosed
US-20250320201-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS AGIOS PHARMACEUTICALS INC (US) 2025-10-16 US disclosed
US-12404286-B2 Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof BORAH, INC. (US) 2025-09-02 US disclosed
EP-4539855-A1 BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF Borah, Inc. (US) 2025-04-23 EP disclosed
CN-1972920-A Arylalkyl piperazine derivatives for the treatment of conditions ameliorated by monoamine reuptake including vasomotor symptoms WYETH CORP (US) 2007-05-30 CN disclosed
EP-1764075-A1 TISSUE FACTOR PRODUCTION INHIBITOR Sankyo Company, Limited (JP) 2007-03-21 EP disclosed
EP-1692111-A2 QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE Wyeth, A Corporation of the State of Delaware (US) 2006-08-23 EP disclosed
WO-2005058834-A2 QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE WYETH (US) 2005-06-30 WO disclosed
US-20050131014-A1 Quinolines useful in treating cardiovascular disease WYETH (US) 2005-06-16 US disclosed
US-6852871-B2 Method for producing optically active salicylaldimine copper complex SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2005-02-08 US disclosed
US-20030233003-A1 Method for producing optically active salicylaldimine copper complex SUMITOMO CHEMICAL COMPANY, LIMITED 2003-12-18 US disclosed
EP-1371631-A1 Method for producing optically active salicylaldimine copper complex SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030233003-A1 Method for producing optically active salicylaldimine copper complex ADH1A, ALDH3A1, ADH1C ERN1 1138/4885TLR2 1719/4885TLR1 286/4885
US-20250382312-A1 BORON CONTAINING PYRAZOLE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF JAK3, JAK1, JAK2 ERN1 1139/4885TLR2 1079/4885TLR1 443/4885
US-20250320201-A1 COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS PAH, KDM8, PHF8 ERN1 1842/4885TLR2 4777/4885TLR1 4706/4885
US-12404286-B2 Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof JAK3, JAK1, JAK2 ERN1 1139/4885TLR2 1079/4885TLR1 443/4885
US-20050131014-A1 Quinolines useful in treating cardiovascular disease NR1H2, NR1H3, SREBF1 ERN1 2548/4885TLR2 923/4885TLR1 490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.