Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262905 | 0.87 | MEN1 (0.33) | GAAL3MBTL1CYP2C19MEN1KMT2A | |
| SCHEMBL11268219 | 0.85 | NR1H3 (0.38) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL11266630 | 0.84 | ALDH1A1 (0.38) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11270936 | 0.79 | RXRA (0.33) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11273159 | 0.75 | STK17A (0.32) | — | |
| SCHEMBL11279682 | 0.74 | THRB (0.36) | GAAHTTALDH1A1 | |
| SCHEMBL11262896 | 0.72 | RORC (0.36) | GAANR1H2NR1H3L3MBTL1CYP2C19 | |
| SCHEMBL11261899 | 0.71 | TACR1 (0.32) | KDM4EGAAMEN1KMT2AHTT | |
| SCHEMBL11266609 | 0.68 | MLYCD (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL11277397 | 0.68 | L3MBTL1 (0.45) | KDM4EL3MBTL1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |