Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432469 | 1.00 | VCAM1 (0.59) | VCAM1GPR35MAPTALDH1A1HPGD | |
| SCHEMBL6825032 | 0.89 | VCAM1 (0.49) | VCAM1GPR35MAPTALDH1A1HPGD | |
| SCHEMBL103929 | 0.85 | VCAM1 (0.64) | VCAM1GPR35MAPTALDH1A1HPGD | |
| SCHEMBL31326843 | 0.85 | VCAM1 (0.64) | VCAM1GPR35MAPTALDH1A1HPGD | |
| SCHEMBL7153973 | 0.83 | GPR35 (0.58) | VCAM1GPR35MAPTALDH1A1HPGD | |
| SCHEMBL4477143 | 0.82 | VCAM1 (0.70) | VCAM1MAPTHPGDLMNACYP3A4 | |
| SCHEMBL4385438 | 0.79 | VCAM1 (0.61) | VCAM1MAPTALDH1A1HPGDCYP1A2 | |
| SCHEMBL16953147 | 0.78 | VCAM1 (0.59) | VCAM1MAPTLMNATDP1KMT2A | |
| SCHEMBL1068675 | 0.78 | VCAM1 (0.59) | VCAM1MAPTALDH1A1LMNAPOLB | |
| SCHEMBL14220808 | 0.78 | VCAM1 (0.59) | VCAM1MAPTHPGDLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |
| US-20240300934-A1 | COMPOUNDS FOR MODULATING MYCOBACTERIUM TUBERCULOSIS RESPONSE | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2024-09-12 | — | — | US | disclosed |
| WO-2023283608-A1 | COMPOUNDS FOR MODULATING MYCOBACTERIUM TUBERCULOSIS RESPONSE | TRUSTEES OF TUFTS COLLEGE (US) | 2023-01-12 | — | — | WO | disclosed |
| US-20190194179-A1 | ANTIBIOTIC COMPOUNDS | DISCUVA LTD. (GB) | 2019-06-27 | — | — | US | disclosed |
| US-20190194179-A1 | ANTIBIOTIC COMPOUNDS | DISCUVA LTD. (GB) | 2019-06-27 | — | — | US | disclosed |
| US-20170298081-A1 | CONDENSED HETEROCYCLIC COMPOUND | KASUMA PARTNERS INC. (JP) | 2017-10-19 | — | — | US | disclosed |
| US-20170298081-A1 | CONDENSED HETEROCYCLIC COMPOUND | KASUMA PARTNERS INC. (JP) | 2017-10-19 | — | — | US | disclosed |
| CN-107001267-A | Condensed heterocyclic compouds | 马合伙人株式会社 | 2017-08-01 | — | — | CN | disclosed |
| EP-3178810-A1 | CONDENSED HETEROCYCLIC COMPOUND | Kasuma Partners Inc. (JP) | 2017-06-14 | — | — | EP | disclosed |
| US-9340505-B2 | Type III secretion inhibitors, analogs and uses thereof | UNIVERSITY OF MASSACHUSETTS (US) | 2016-05-17 | — | — | US | disclosed |
| US-5840764-A | SMOOTH MUSCLE RELAXANTS FOR TREATMENT OF URINARY INCONTINENCE OR IRRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |
| WO-1998033763-A1 | SUBSTITUTED HYDROXY-ANILINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-06 | — | — | WO | disclosed |
| US-5780483-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| CN-1174829-A | Selective nitration of phenol derivatives | JUNSEI CHEMICAL (JP) | 1998-03-04 | — | — | CN | disclosed |
| WO-1998006397-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |
| WO-1998005328-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |
| WO-1996028443-A1 | THERAPEUTIC BENZOXAZOLES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-09-19 | — | — | WO | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300934-A1 | COMPOUNDS FOR MODULATING MYCOBACTERIUM TUBERCULOSIS RESPONSE | IFNG, NFATC1, RELA | VCAM1 2982/4885GPR35 2500/4885MAPT 3282/4885 |
| US-20190194179-A1 | ANTIBIOTIC COMPOUNDS | B3GNT2, RPN2, RPN1 | VCAM1 4265/4885GPR35 1158/4885MAPT 1807/4885 |
| US-20170298081-A1 | CONDENSED HETEROCYCLIC COMPOUND | APOB, NPC1, NPC1L1 | VCAM1 1029/4885GPR35 2980/4885MAPT 3961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.