Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 3/20 | 0.36 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146885 | 0.96 | MAPT (0.44) | TLR8MAPTGPR84ATMGAA | |
| SCHEMBL6545632 | 0.94 | MAPT (0.46) | TLR8MAPTGAA | |
| SCHEMBL1146279 | 0.94 | MAPT (0.46) | TLR8MAPTGAA | |
| SCHEMBL1146688 | 0.94 | MAPT (0.46) | TLR8MAPTGAA | |
| SCHEMBL66353 | 0.89 | TLR8 (0.40) | TLR8MAPTGPR84ATMESR1 | |
| SCHEMBL31516528 | 0.89 | TLR8 (0.40) | TLR8MAPTGPR84ATMESR1 | |
| Water SCHEMBL9133681 | 0.88 | TLR8 (0.39) | TLR8MAPTGPR84ATMESR1 | |
| SCHEMBL11248199 | 0.87 | L3MBTL1 (0.47) | TLR8MAPTGPR84ATMESR1 | |
| Formaldehyde SCHEMBL11114952 | 0.87 | TLR8 (0.38) | TLR8MAPTGPR84ATMESR1 | |
| Lithium Ion SCHEMBL550303 | 0.86 | TLR8 (0.40) | TLR8MAPTGPR84ATMESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7883830-B2 | Photosensitive planographic printing plate | Kodak Japan Ltd. and NEC Engineering Ltd. (JP) | 2011-02-08 | — | — | US | disclosed |
| US-20080280228-A1 | With a photosensitive layer; a photopolymerizable compound, a copolymer undercoat layer from alkoxyvinyl silanes, polyethers, vinyl phosphoric acid, acrylic monomers | KODAK GRAPHIC COMMUNICATIONS JAPAN LTD. (JP) | 2008-11-13 | — | — | US | disclosed |
| EP-1865378-A1 | PHOTOSENSITIVE LITHOGRAPHIC PRINTING PLATE | Kodak Graphic Communications Japan Ltd. (JP) | 2007-12-12 | — | — | EP | disclosed |