Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11551530 | 0.88 | KDM4E (0.44) | PRNPRXFP1HSD11B1CMA1MAOB | |
| SCHEMBL11559959 | 0.86 | HSD11B1 (0.43) | PRNPRXFP1HSD11B1CMA1MAOB | |
| SCHEMBL11555267 | 0.86 | MMP2 (0.48) | PRNPRXFP1HSD11B1MAOBACLY | |
| SCHEMBL11554622 | 0.85 | GSTO1 (0.41) | PRNPCMA1ACLYGSTO1MAPT | |
| SCHEMBL11556895 | 0.85 | TP53 (0.42) | PRNPRXFP1HSD11B1CMA1MAOB | |
| SCHEMBL11560887 | 0.81 | CNR2 (0.53) | ACLYGSTO1MAPTNPC1RAB9A | |
| SCHEMBL11552566 | 0.75 | KDM4E (0.44) | MAOBACLYGABRA1GABRA5GSTO1 | |
| SCHEMBL11559300 | 0.75 | RORC (0.43) | ACLYGSTO1MAPTPOLBHSD17B10 | |
| SCHEMBL11554835 | 0.75 | ACLY (0.43) | ACLYGSTO1MAPTPOLBHSD17B10 | |
| SCHEMBL11553624 | 0.74 | CYP2C19 (0.53) | GSTO1MAPTPOLBHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |