SCHEMBL1158723

SCHEMBL1158723

C=CCB(CC=C)c1ccc(F)cc1CC=C

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.33
GABRB2 P47870 3/20 0.33
LMNA P02545 1/20 0.32
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
ALDH2 P05091 1/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30
AKR1B1 P15121 1/20 0.30
HPGD P15428 1/20 0.30
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30
PPARG P37231 1/20 0.30
KMT2A Q03164 1/20 0.30
PPARD Q03181 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1158972 0.81 LMNA (0.32) GABRA1GABRB2LMNAKDM4EMEN1
SCHEMBL7167552 0.79 L3MBTL1 (0.36) GABRA1GABRB2LMNAKDM4EMEN1
SCHEMBL1158905 0.79 PTGDR (0.43) GABRA1GABRB2LMNAKDM4EMEN1
SCHEMBL7165637 0.77 GABRA1 (0.35) GABRA1GABRB2KDM4EMEN1ALDH1A1
SCHEMBL7164350 0.76 ALDH1A1 (0.46) GABRA1GABRB2LMNAMEN1ALDH1A1
SCHEMBL1158664 0.74 GABRA1 (0.41) GABRA1GABRB2LMNAKDM4EALDH1A1
SCHEMBL12833025 0.74 PSEN1 (0.40) GABRA1GABRB2LMNAALDH1A1PPARG
SCHEMBL1158934 0.73 POLB (0.36) LMNAKDM4EMEN1ALDH1A1MAPT
SCHEMBL7168148 0.73 KDM4E (0.39) GABRA1GABRB2LMNAKDM4EMEN1
SCHEMBL1158940 0.72 THRB (0.37) GABRA1GABRB2KDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240164993-A1 ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME KURARAY NORITAKE DENTAL INC. (JP) 2024-05-23 US disclosed
US-20230381066-A1 DENTAL CURABLE COMPOSITION HAVING GOOD COLOR COMPATIBILITY KURARAY NORITAKE DENTAL INC. (JP) 2023-11-30 US disclosed
EP-2979679-B1 CURABLE COMPOSITION FOR DENTAL USE KURARAY NORITAKE DENTAL INC (JP) 2023-11-29 EP disclosed
EP-4268791-A1 ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME Kuraray Noritake Dental Inc. (JP) 2023-11-01 EP disclosed
EP-3363424-B1 DENTAL CURABLE COMPOSITION HAVING HIGH MECHANICAL STRENGTH SHOFU KK (JP) 2023-10-25 EP disclosed
EP-2216349-B1 USE OF A PHENOL TYPE COMPOUND IN A DENTAL CHEMICAL POLYMERIZATION CATALYST WITH IMPROVED POLYMERIZING ACTIVITY TOKUYAMA DENTAL CORP (JP) 2023-09-20 EP disclosed
EP-4238546-A1 DENTAL CURABLE COMPOSITION HAVING GOOD COLOR COMPATIBILITY Kuraray Noritake Dental Inc. (JP) 2023-09-06 EP disclosed
US-20230255857-A1 DENTAL COMPOSITION CONTAINING ION SUSTAINED-RELEASE GLASS SHOFU INC. (JP) 2023-08-17 US disclosed
US-11648184-B2 Dental composition containing ion sustained-release glass SHOFU INC. (JP) 2023-05-16 US disclosed
US-11607370-B2 Dental composition KURARAY NORITAKE DENTAL INC. (JP) 2023-03-21 US disclosed
US-20020022677-A1 Dental composite material comprising aggregate KABUSHIKI KAISHA SHOFU (JP) 2002-02-21 US disclosed
EP-1149573-A2 A dental composite material comprising aggregate KABUSHIKI KAISHA SHOFU (JP) 2001-10-31 EP disclosed
EP-0738928-B1 Visible-ray polymerization initiator and visible-ray polymerizable composition TOKUYAMA CORP (JP) 2001-06-20 EP disclosed
EP-0712622-B1 Dental composition and kit TOKUYAMA CORP (JP) 1999-09-01 EP disclosed
US-5925690-A UNSATURATED PHOSPHATE AND UNSATURATED POLYCARBOXYLIC ACID MONOMERS; BONDING AND TENSILE STRENGTH TO DENTIN AND ENAMEL TOKUYAMA CORPROATION (JP) 1999-07-20 US disclosed
US-5866631-A POLYMERIZABLE MONOMER CONTAINING AN ACIDIC GROUP, WATER, ARYL BORATE AND TRANSITION METAL COMPOUND. TOKUYAMA CORPORATION (JP) 1999-02-02 US disclosed
US-5744511-A BLEND OF COUMARIN DYES, ACID GENERATOR AND ARYL BORATE TOKUYAMA CORPORATION (JP) 1998-04-28 US disclosed
EP-0811368-A1 DENTAL PRIMER COMPOSITION AND POLYMERIZATION CATALYST TOKUYAMA CORPORATION (JP) 1997-12-10 EP disclosed
EP-0738928-A2 Visible-ray polymerization initiator and visible-ray polymerizable composition TOKUYAMA CORPORATION (JP) 1996-10-23 EP disclosed
EP-0712622-A1 Dental composition and kit TOKUYAMA CORPORATION (JP) 1996-05-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11607370-B2 Dental composition ITGAL, ITGA1, ITGB3 GABRA1 4129/4885GABRB2 4593/4885LMNA 737/4885
US-20230255857-A1 DENTAL COMPOSITION CONTAINING ION SUSTAINED-RELEASE GLASS SLCO2B1, CA2, SLCO2A1 GABRA1 792/4885GABRB2 852/4885LMNA 3444/4885
US-11648184-B2 Dental composition containing ion sustained-release glass SLCO2B1, CA2, SLCO2A1 GABRA1 792/4885GABRB2 852/4885LMNA 3444/4885
US-20240164993-A1 ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME MSL1, ITGA1, ASH2L GABRA1 4017/4885GABRB2 4258/4885LMNA 3123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.