SCHEMBL1158905

SCHEMBL1158905

C=CCB(CC=C)c1ccc(Cl)cc1CC=C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR Q13258 1/20 0.43
PTGDR2 Q9Y5Y4 1/20 0.43
MAPT P10636 5/20 0.40
KDM4E B2RXH2 9/20 0.35
LMNA P02545 3/20 0.35
THRB P10828 1/20 0.35
ALDH1A1 P00352 8/20 0.34
MEN1 O00255 5/20 0.34
KMT2A Q03164 5/20 0.34
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
POLB P06746 1/20 0.33
CYP3A4 P08684 2/20 0.32
SLC22A1 O15245 1/20 0.32
USP2 O75604 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HSPD1 P10809 1/20 0.32
HSPA5 P11021 1/20 0.32
IDO1 P14902 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1158784 0.81 PTGDR (0.40) PTGDRPTGDR2MAPTKDM4ELMNA
SCHEMBL1158723 0.79 GABRA1 (0.33) MAPTKDM4ELMNAALDH1A1MEN1
SCHEMBL7167552 0.79 L3MBTL1 (0.36) MAPTKDM4ELMNAALDH1A1MEN1
SCHEMBL7165637 0.77 GABRA1 (0.35) MAPTKDM4EALDH1A1MEN1KMT2A
SCHEMBL7164350 0.76 ALDH1A1 (0.46) MAPTLMNAALDH1A1MEN1KMT2A
SCHEMBL1158664 0.74 GABRA1 (0.41) KDM4ELMNAALDH1A1GABRA1GABRB2
SCHEMBL15066541 0.74 PTGDR (0.50) PTGDRPTGDR2MAPTKDM4ELMNA
SCHEMBL1158934 0.73 POLB (0.36) MAPTKDM4ELMNAALDH1A1MEN1
SCHEMBL7168148 0.73 KDM4E (0.39) MAPTKDM4ELMNAALDH1A1MEN1
SCHEMBL1158940 0.72 THRB (0.37) MAPTKDM4ETHRBALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240164993-A1 ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME KURARAY NORITAKE DENTAL INC. (JP) 2024-05-23 US disclosed
US-11866590-B2 Diisocyanate-based radical polymerizable silane coupling compound having an urethane bond KABUSHIKI KAISHA SHOFU (JP) 2024-01-09 US disclosed
US-20230381066-A1 DENTAL CURABLE COMPOSITION HAVING GOOD COLOR COMPATIBILITY KURARAY NORITAKE DENTAL INC. (JP) 2023-11-30 US disclosed
EP-2979679-B1 CURABLE COMPOSITION FOR DENTAL USE KURARAY NORITAKE DENTAL INC (JP) 2023-11-29 EP disclosed
EP-4268791-A1 ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME Kuraray Noritake Dental Inc. (JP) 2023-11-01 EP disclosed
EP-2216349-B1 USE OF A PHENOL TYPE COMPOUND IN A DENTAL CHEMICAL POLYMERIZATION CATALYST WITH IMPROVED POLYMERIZING ACTIVITY TOKUYAMA DENTAL CORP (JP) 2023-09-20 EP disclosed
EP-4238546-A1 DENTAL CURABLE COMPOSITION HAVING GOOD COLOR COMPATIBILITY Kuraray Noritake Dental Inc. (JP) 2023-09-06 EP disclosed
US-11737957-B2 Dental curable composition including chain transfer agent SHOFU INC. (JP) 2023-08-29 US disclosed
WO-2023120611-A1 CURABLE DENTAL COMPOSITION クラレノリタケデンタル株式会社 2023-06-29 WO disclosed
WO-2023120610-A1 DENTAL CURABLE COMPOSITION クラレノリタケデンタル株式会社 2023-06-29 WO disclosed
US-20020132951-A1 Dental catalyst for chemical polymerization and use thereof TOKUYAMA CORPORATION 2002-09-19 US disclosed
EP-1190695-A1 Catalyst for chemical polymerization of dental materials TOKUYAMA CORPORATION (JP) 2002-03-27 EP disclosed
EP-0738928-B1 Visible-ray polymerization initiator and visible-ray polymerizable composition TOKUYAMA CORP (JP) 2001-06-20 EP disclosed
EP-0712622-B1 Dental composition and kit TOKUYAMA CORP (JP) 1999-09-01 EP disclosed
US-5925690-A UNSATURATED PHOSPHATE AND UNSATURATED POLYCARBOXYLIC ACID MONOMERS; BONDING AND TENSILE STRENGTH TO DENTIN AND ENAMEL TOKUYAMA CORPROATION (JP) 1999-07-20 US disclosed
US-5866631-A POLYMERIZABLE MONOMER CONTAINING AN ACIDIC GROUP, WATER, ARYL BORATE AND TRANSITION METAL COMPOUND. TOKUYAMA CORPORATION (JP) 1999-02-02 US disclosed
US-5744511-A BLEND OF COUMARIN DYES, ACID GENERATOR AND ARYL BORATE TOKUYAMA CORPORATION (JP) 1998-04-28 US disclosed
EP-0811368-A1 DENTAL PRIMER COMPOSITION AND POLYMERIZATION CATALYST TOKUYAMA CORPORATION (JP) 1997-12-10 EP disclosed
EP-0738928-A2 Visible-ray polymerization initiator and visible-ray polymerizable composition TOKUYAMA CORPORATION (JP) 1996-10-23 EP disclosed
EP-0712622-A1 Dental composition and kit TOKUYAMA CORPORATION (JP) 1996-05-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11866590-B2 Diisocyanate-based radical polymerizable silane coupling compound having an urethane bond CAD, DCLRE1A, STIM1 PTGDR 1091/4885PTGDR2 690/4885MAPT 754/4885
US-20240164993-A1 ORGANOSILICON COMPOUND AND DENTAL COMPOSITION CONTAINING SAME MSL1, ITGA1, ASH2L PTGDR 2473/4885PTGDR2 2055/4885MAPT 4720/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.