SCHEMBL1158784

SCHEMBL1158784

C=CCB(c1ccc(Cl)cc1)c1ccc(Cl)cc1CC=C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR Q13258 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40
MAPT P10636 5/20 0.34
ALDH1A1 P00352 8/20 0.34
L3MBTL1 Q9Y468 3/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
LMNA P02545 4/20 0.33
KDM4E B2RXH2 9/20 0.33
POLB P06746 2/20 0.33
THRB P10828 1/20 0.33
MEN1 O00255 4/20 0.32
KMT2A Q03164 4/20 0.32
HPGD P15428 2/20 0.31
GABRA1 P14867 2/20 0.30
GABRB2 P47870 2/20 0.30
ALDH2 P05091 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1158905 0.81 PTGDR (0.43) PTGDRPTGDR2MAPTALDH1A1L3MBTL1
SCHEMBL1158972 0.79 LMNA (0.32) MAPTALDH1A1LMNAKDM4EMEN1
SCHEMBL7160494 0.79 L3MBTL1 (0.36) MAPTALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL7163601 0.77 LPL (0.35) MAPTALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL7159511 0.75 ALDH1A1 (0.45) MAPTALDH1A1L3MBTL1CYP3A4LMNA
SCHEMBL1426511 0.73 POLB (0.34) MAPTALDH1A1LMNAPOLBMEN1
SCHEMBL7161860 0.73 KDM4E (0.41) MAPTALDH1A1L3MBTL1LMNAKDM4E
SCHEMBL1159144 0.72 CA1 (0.41) MAPTALDH1A1KDM4ETHRBMEN1
SCHEMBL1158686 0.71 GABRA1 (0.37) MAPTALDH1A1KDM4ETHRBMEN1
SCHEMBL15066541 0.69 PTGDR (0.50) PTGDRPTGDR2MAPTALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866590-B2 Diisocyanate-based radical polymerizable silane coupling compound having an urethane bond KABUSHIKI KAISHA SHOFU (JP) 2024-01-09 US disclosed
EP-2979679-B1 CURABLE COMPOSITION FOR DENTAL USE KURARAY NORITAKE DENTAL INC (JP) 2023-11-29 EP disclosed
WO-2023182514-A1 ADHESIVE COMPOSITION FOR STEREOLITHOGRAPHIC ARTICLE AND NON-STEREOLITHOGRAPHIC ARTICLE クラレノリタケデンタル株式会社 2023-09-28 WO disclosed
EP-2216349-B1 USE OF A PHENOL TYPE COMPOUND IN A DENTAL CHEMICAL POLYMERIZATION CATALYST WITH IMPROVED POLYMERIZING ACTIVITY TOKUYAMA DENTAL CORP (JP) 2023-09-20 EP disclosed
WO-2023120611-A1 CURABLE DENTAL COMPOSITION クラレノリタケデンタル株式会社 2023-06-29 WO disclosed
WO-2023120610-A1 DENTAL CURABLE COMPOSITION クラレノリタケデンタル株式会社 2023-06-29 WO disclosed
US-11607370-B2 Dental composition KURARAY NORITAKE DENTAL INC. (JP) 2023-03-21 US disclosed
US-20210395532-A1 DIISOCYANATE-BASED RADICAL POLYMERIZABLE SILANE COUPLING COMPOUND HAVING AN URETHANE BOND KABUSHIKI KAISHA SHOFU (JP) 2021-12-23 US disclosed
US-11173100-B2 Multi-part dental cement KURARAY NORITAKE DENTAL INC. (JP) 2021-11-16 US disclosed
EP-3530258-B1 MULTI-PACK TYPE DENTAL CEMENT KURARAY NORITAKE DENTAL INC (JP) 2021-08-18 EP disclosed
US-20020132951-A1 Dental catalyst for chemical polymerization and use thereof TOKUYAMA CORPORATION 2002-09-19 US disclosed
EP-1190695-A1 Catalyst for chemical polymerization of dental materials TOKUYAMA CORPORATION (JP) 2002-03-27 EP disclosed
EP-0738928-B1 Visible-ray polymerization initiator and visible-ray polymerizable composition TOKUYAMA CORP (JP) 2001-06-20 EP disclosed
EP-0712622-B1 Dental composition and kit TOKUYAMA CORP (JP) 1999-09-01 EP disclosed
US-5925690-A UNSATURATED PHOSPHATE AND UNSATURATED POLYCARBOXYLIC ACID MONOMERS; BONDING AND TENSILE STRENGTH TO DENTIN AND ENAMEL TOKUYAMA CORPROATION (JP) 1999-07-20 US disclosed
US-5866631-A POLYMERIZABLE MONOMER CONTAINING AN ACIDIC GROUP, WATER, ARYL BORATE AND TRANSITION METAL COMPOUND. TOKUYAMA CORPORATION (JP) 1999-02-02 US disclosed
US-5744511-A BLEND OF COUMARIN DYES, ACID GENERATOR AND ARYL BORATE TOKUYAMA CORPORATION (JP) 1998-04-28 US disclosed
EP-0811368-A1 DENTAL PRIMER COMPOSITION AND POLYMERIZATION CATALYST TOKUYAMA CORPORATION (JP) 1997-12-10 EP disclosed
EP-0738928-A2 Visible-ray polymerization initiator and visible-ray polymerizable composition TOKUYAMA CORPORATION (JP) 1996-10-23 EP disclosed
EP-0712622-A1 Dental composition and kit TOKUYAMA CORPORATION (JP) 1996-05-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11607370-B2 Dental composition ITGAL, ITGA1, ITGB3 PTGDR 4200/4885PTGDR2 4386/4885MAPT 3826/4885
US-11173100-B2 Multi-part dental cement ASH2L, CAD, SETDB1 PTGDR 1418/4885PTGDR2 867/4885MAPT 2401/4885
US-11866590-B2 Diisocyanate-based radical polymerizable silane coupling compound having an urethane bond CAD, DCLRE1A, STIM1 PTGDR 1091/4885PTGDR2 690/4885MAPT 754/4885
US-20210395532-A1 DIISOCYANATE-BASED RADICAL POLYMERIZABLE SILANE COUPLING COMPOUND HAVING AN URETHANE BOND CAD, DCLRE1A, STIM1 PTGDR 1091/4885PTGDR2 690/4885MAPT 754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.