Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | SLC25A1 | P53007 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11846360 | 0.84 | PKM (0.60) | PKML3MBTL1SLC25A1SMN1; SMN2LMNA | |
| SCHEMBL11780616 | 0.83 | PKM (0.59) | PKML3MBTL1SMN1; SMN2LMNACRHBP | |
| SCHEMBL11847710 | 0.78 | HCAR3 (0.47) | SLC25A1LMNATSHRPOLBHCAR3 | |
| SCHEMBL28945979 | 0.76 | MAPT (0.44) | SLC25A1LMNATSHRPOLBHCAR3 | |
| SCHEMBL30241160 | 0.76 | MAPT (0.44) | SLC25A1LMNATSHRPOLBHCAR3 | |
| SCHEMBL7826598 | 0.74 | VCAM1 (0.49) | LMNATSHRPOLBHCAR3MAPT | |
| SCHEMBL135289 | 0.72 | CASP6 (0.47) | LMNATSHRPOLBHCAR3MAPT | |
| Methylamine SCHEMBL11877019 | 0.71 | TSHR (0.44) | LMNATSHRPOLBHCAR3MAPT | |
| SCHEMBL11802836 | 0.71 | GAA (0.57) | LMNAHCAR3MAPT | |
| SCHEMBL31108456 | 0.71 | ALDH1A1 (0.57) | LMNATSHRPOLBHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3939267-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |
| US-3933906-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |