Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11836770 | 0.85 | PTGS2 (0.37) | PTGS2LMNAMAPK1MMP2MMP13 | |
| SCHEMBL11840724 | 0.84 | PTGS2 (0.38) | PTGS2LMNAMMP2MMP13MMP1 | |
| SCHEMBL11841177 | 0.82 | MGLL (0.41) | MMP2MMP1MMP12MCL1 | |
| SCHEMBL15577018 | 0.80 | RXRA (0.35) | PTGS2 | |
| SCHEMBL11841735 | 0.76 | PPARG (0.47) | PTGS2LMNAMAPK1CYP1A2GAA | |
| SCHEMBL10192324 | 0.75 | MMP1 (0.32) | PTGS2LMNAMMP2MMP13MMP1 | |
| SCHEMBL10247815 | 0.75 | TSHR (0.39) | PTGS2CYP1A2ADAMTS4FFAR1MAPT | |
| SCHEMBL11839204 | 0.74 | ACMSD (0.53) | PTGS2LMNAMAPK1GAAMAPT | |
| SCHEMBL11834761 | 0.74 | LMNA (0.44) | PTGS2LMNAMAPK1CYP1A2GAA | |
| SCHEMBL11841217 | 0.73 | CRHBP (0.44) | PTGS2LMNAMAPK1CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3941821-A | ANTIINFLAMMATORY, ANALGESICS, ANTIPYRETICS | WILLIAM H. RORER, INC. (US) | 1976-03-02 | — | — | US | disclosed |