Sugi Predict

Sugi Predict / Compounds / SCHEMBL1189439

SCHEMBL1189439

SCHEMBL1189439

CC(=O)c1cccc(Cl)c1N

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.45
▸ CES2 O00748 1/20 0.45
▸ CES1 P23141 1/20 0.45
▸ ALDH1A1 P00352 6/20 0.43
▸ LMNA P02545 2/20 0.42
▸ GAA P10253 1/20 0.42
▸ POLB P06746 1/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ KDM4E B2RXH2 3/20 0.41
▸ RECQL P46063 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ HPGD P15428 2/20 0.40
▸ CYP1A2 P05177 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ HAVCR2 Q8TDQ0 1/20 0.40
▸ G6PD P11413 1/20 0.39
▸ CASP7 P55210 1/20 0.39
▸ CASP6 P55212 1/20 0.39
▸ KLKB1 P03952 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3498784 0.84 G6PD (0.46) TSHRALDH1A1LMNAGAAKMT2A
SCHEMBL11845879 0.81 CES2 (0.44) TSHRCES2CES1ALDH1A1LMNA
SCHEMBL27656646 0.81 KMT2A (0.38) TSHRALDH1A1KMT2AKDM4EHPGD
SCHEMBL161331 0.81 KDM4E (0.53) TSHRCES2CES1ALDH1A1LMNA
SCHEMBL4096953 0.81 ALDH1A1 (0.52) TSHRCES2CES1ALDH1A1LMNA
SCHEMBL146560 0.81 TSHR (0.63) TSHRCES2CES1ALDH1A1LMNA
SCHEMBL2869896 0.80 FEN1 (0.46) TSHRCES2CES1ALDH1A1LMNA
SCHEMBL10622677 0.79 PKM (0.44) CES2CES1ALDH1A1LMNAKMT2A
SCHEMBL23029353 0.79 ALDH1A1 (0.39) TSHRCES2CES1ALDH1A1LMNA
SCHEMBL3917269 0.79 ALDH1A1 (0.42) TSHRALDH1A1LMNAGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12263165-B2 Small molecule inhibitors of cancer stem cells and mesenchymal cancer types THE SCRIPPS RESEARCH INSTITUTE (US) 2025-04-01 — — US disclosed
CN-116514712-B Synthesis method of 3-benzyl-2-phenyl-4-quinolone compound 延安大学 2024-09-06 — — CN disclosed
US-20240197729-A1 ALK-5 Inhibitors and Uses Thereof SUMITOMO PHARMA ONCOLOGY INC (US) 2024-06-20 — — US disclosed
EP-4313052-A1 ALK-5 INHIBITORS AND USES THEREOF Sumitomo Pharma Oncology, Inc. (US) 2024-02-07 — — EP disclosed
CN-117355304-A ALK-5 inhibitors and uses thereof 住友制药肿瘤公司 2024-01-05 — — CN disclosed
US-20230346781-A1 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES THE SCRIPPS RESEARCH INSTITUTE (US) 2023-11-02 — — US disclosed
US-20230346781-A1 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES THE SCRIPPS RESEARCH INSTITUTE (US) 2023-11-02 — — US disclosed
US-20230346781-A1 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES THE SCRIPPS RESEARCH INSTITUTE (US) 2023-11-02 — — US disclosed
EP-4259145-A1 ALK-5 INHIBITORS AND USES THEREOF Sumitomo Pharma Oncology, Inc. (US) 2023-10-18 — — EP disclosed
US-11759461-B2 Small molecule inhibitors of cancer stem cells and mesenchymal cancer types THE SCRIPPS RESEARCH INSTITUTE (US) 2023-09-19 — — US disclosed
US-20170014419-A1 MEDICAMENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER (JP) 2017-01-19 — — US disclosed
WO-2015144001-A1 QUINOLINE DERIVATIVES AS SMO INHIBITORS 南京明德新药研发股份有限公司 2015-10-01 — — WO disclosed
CN-101460237-B Modified membrane DOW GLOBAL TECHNOLOGIES INC 2013-09-04 — — CN disclosed
US-8461209-B2 Malonic acid sulfonamide derivative and pharmaceutical use thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-06-11 — — US disclosed
WO-2013050527-A1 QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2013-04-11 — — WO disclosed
US-20110155660-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES LLC 2011-06-30 — — US disclosed
US-7882963-B2 modifying polyamide discriminating layer ( e.g metaphenylene diamine- trimesoyl chloride monomers) with aminoacetophenone or aminothiophenol; fouling resistant surface, improved salt rejection, antimicrobial properties, improved solute, and/or small organics rejection; for water purification DOW GLOBAL TECHNOLOGIES INC. (US) 2011-02-08 — — US disclosed
US-20090159527-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES LLC 2009-06-25 — — US disclosed
CN-101460237-A Modified membrane DOW GLOBAL TECHNOLOGIES INC (US) 2009-06-17 — — CN disclosed
WO-2007133362-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES INC. (US) 2007-11-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197729-A1 ALK-5 Inhibitors and Uses Thereof ACVR1, ALK, ACVRL1 TSHR 607/4885CES2 4099/4885CES1 1650/4885
US-12263165-B2 Small molecule inhibitors of cancer stem cells and mesenchymal cancer types VIM, CDH1, BRCA1 TSHR 4116/4885CES2 3757/4885CES1 3095/4885
US-20230346781-A1 SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES VIM, CDH1, BRCA1 TSHR 4116/4885CES2 3757/4885CES1 3095/4885
US-11759461-B2 Small molecule inhibitors of cancer stem cells and mesenchymal cancer types VIM, BRCA1, CDH1 TSHR 4108/4885CES2 4043/4885CES1 3270/4885
US-20170014419-A1 MEDICAMENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS AGTR2, MME, AGTR1 TSHR 1343/4885CES2 3660/4885CES1 1597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.