Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18533548 | 0.78 | TSHR (0.54) | ALDH1A1HSD17B10TSHRTP53MAPK1 | |
| SCHEMBL234461 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HSD17B10TSHRTP53MAPK1 | |
| SCHEMBL97582 | 0.76 | CA1 (0.52) | CA1CA2ALDH1A1TSHRCYP3A4 | |
| SCHEMBL27473140 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HSD17B10TSHRTP53MAPK1 | |
| SCHEMBL8267536 | 0.74 | PLAU (0.52) | CA2ALDH1A1HSD17B10TSHRTP53 | |
| SCHEMBL4556165 | 0.74 | NOS3 (0.52) | CA1CA2ALDH1A1HSD17B10TSHR | |
| SCHEMBL28211979 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TSHRTP53MAPK1 | |
| SCHEMBL11287516 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TSHRTP53MAPK1 | |
| SCHEMBL8505290 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HSD17B10TSHRTP53MAPK1 | |
| SCHEMBL26748418 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HSD17B10TSHRTP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210061782-A1 | Diamine Compound with Meldrum's Acid Group and Related Polymer Thereof | NATIONAL TSING HUA UNIVERSITY (TW) | 2021-03-04 | — | — | US | disclosed |
| CN-106749227-B | Berberine azole derivative of ketenes bridging and its preparation method and application | 西南大学 | 2018-08-14 | — | — | CN | disclosed |
| CN-104768932-B | The heteroaryl inhibitors of PDE4 | 泰特拉探索合伙有限责任公司 | 2018-08-07 | — | — | CN | disclosed |
| CN-106467478-B | Vanillin derivative, preparation method and use containing dithioacetals | 贵州大学 | 2018-05-15 | — | — | CN | disclosed |
| CN-105288724-B | Utilize the method for curcumin derivate processing titania nanotube | 广西中医药大学 | 2018-04-06 | — | — | CN | disclosed |
| CN-107011400-A | Asymmetric auxiliary group | 日本波涛生命科学公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-106749227-A | Berberine azole derivative of ketenes bridging and its preparation method and application | 西南大学 | 2017-05-31 | — | — | CN | disclosed |
| CN-106701061-A | GPR120 (G-protein Coupled Receptor 120) small-molecule fluorescent probe and application of GPR120 small-molecule fluorescent probe | 山东大学 | 2017-05-24 | — | — | CN | disclosed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
| US-20080103189-A1 | PREPARATION AND UTILITY OF SUBSTITUTED INDOLES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061782-A1 | Diamine Compound with Meldrum's Acid Group and Related Polymer Thereof | DDC, DAO, TLR5 | CA1 1683/4885CA2 3173/4885ALDH1A1 261/4885 |
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | CA1 4816/4885CA2 3991/4885ALDH1A1 2281/4885 |
| US-20080103189-A1 | PREPARATION AND UTILITY OF SUBSTITUTED INDOLES | IDO1, TPH1, IDO2 | CA1 2892/4885CA2 4082/4885ALDH1A1 174/4885 |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CA1 2849/4885CA2 1401/4885ALDH1A1 4063/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CA1 2849/4885CA2 1401/4885ALDH1A1 4063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.