Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8692630 | 0.87 | CES2 (0.46) | ALDH1A1TSHRTRPA1HSD17B10TP53 | |
| SCHEMBL12663034 | 0.80 | TDP1 (0.48) | ALDH1A1TSHRHSD17B10TP53MAPK1 | |
| SCHEMBL18533548 | 0.78 | TSHR (0.54) | ALDH1A1TSHRHSD17B10TP53MAPK1 | |
| SCHEMBL9822956 | 0.78 | ALDH1A1 (0.48) | ALDH1A1TSHRTRPA1HSD17B10MAPK1 | |
| SCHEMBL15821556 | 0.78 | ALDH1A1 (0.48) | ALDH1A1TSHRTRPA1HSD17B10MAPK1 | |
| SCHEMBL234461 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TSHRHSD17B10TP53MAPK1 | |
| SCHEMBL131361 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TSHRTRPA1CES2CES1 | |
| SCHEMBL10073625 | 0.76 | TSHR (0.46) | ALDH1A1TSHRTRPA1CES2CES1 | |
| SCHEMBL27473140 | 0.76 | ALDH1A1 (0.42) | ALDH1A1TSHRHSD17B10TP53MAPK1 | |
| SCHEMBL12134592 | 0.74 | CA1 (0.43) | ALDH1A1TSHRHSD17B10TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |
| CN-108026026-A | Beta-amino acids and analog and its application as the β-substituted of chemotherapeutics | 夸德里加生物科学公司 | 2018-05-11 | — | — | CN | disclosed |
| US-20170283442-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | IMMUNOMEDICS, INC. | 2017-10-05 | — | — | US | disclosed |
| US-8314134-B2 | Compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20120245077-A1 | PROKINETICIN 1 RECEPTOR | MABUS JOHN R (US) | 2012-09-27 | — | — | US | disclosed |
| WO-2012082618-A2 | METHODS AND COMPOSITIONS FOR IMPROVED F-18 LABELING OF PROTEINS, PEPTIDES AND OTHER MOLECULES | IMMUNOMEDICS, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-8188081-B2 | Methods of treating inflammation using prokineticin 1 receptor antagonists | JANSSEN PHARMACEUTICA, NV (BE) | 2012-05-29 | — | — | US | disclosed |
| US-20120129862-A1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | COATS STEVEN J (US) | 2012-05-24 | — | — | US | disclosed |
| US-8163777-B2 | Benzimidazolyl-pyridine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-04-24 | — | — | US | disclosed |
| US-7968710-B2 | Gastrointestinal disorders;inflammatory bowel disorders; gastroesophageal reflux; constipation | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-28 | — | — | US | disclosed |
| US-20110136811-A1 | PROKINETICIN 1 RECEPTOR | MABUS JOHN R | 2011-06-09 | — | — | US | disclosed |
| US-20100311787-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2010-12-09 | — | — | US | disclosed |
| US-20100267634-A1 | Anti-Viral Compounds | Abbott Labaoratories (US) | 2010-10-21 | — | — | US | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | TARGANTA THERAPEUTICA INC. (CA) | 2008-11-20 | — | — | US | disclosed |
| WO-1998011077-A1 | MATERIALS FOR CHIROOPTICAL DEVICES | CHISSO CORPORATION (JP) | 1998-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267634-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | ALDH1A1 2858/4885TSHR 4834/4885TRPA1 4273/4885 |
| US-20080287396-A1 | Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections | BPGM, PSPH, PGLS | ALDH1A1 4175/4885TSHR 4446/4885TRPA1 4855/4885 |
| US-20100311787-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | CXCR2, CXCL8, CCR9 | ALDH1A1 1952/4885TSHR 4256/4885TRPA1 504/4885 |
| US-20110136811-A1 | PROKINETICIN 1 RECEPTOR | PROKR1, PROKR2, GIPR | ALDH1A1 3305/4885TSHR 129/4885TRPA1 1716/4885 |
| US-20120129862-A1 | PROKINETICIN 1 RECEPTOR ANTAGONISTS | PROKR1, PROKR2, GIPR | ALDH1A1 3674/4885TSHR 228/4885TRPA1 1790/4885 |
| US-20120245077-A1 | PROKINETICIN 1 RECEPTOR | PROKR1, PROKR2, GIPR | ALDH1A1 3305/4885TSHR 129/4885TRPA1 1716/4885 |
| US-20170283442-A1 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules | F13B, PAICS, MRPL19 | ALDH1A1 4430/4885TSHR 468/4885TRPA1 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.