Alpdem

Alpdem

SCHEMBL1230701

CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2c(Cl)cc(Cl)cn12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TSPO P30536 6/20 1.00
▸ GMNN O75496 1/20 1.00
▸ LMNA P02545 1/20 1.00
▸ POLB P06746 1/20 1.00
▸ CYP3A4 P08684 1/20 1.00
▸ BLM P54132 1/20 1.00
▸ NPSR1 Q6W5P4 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22627545 0.95 TSPO (0.90) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL30849696 0.93 TSPO (0.86) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL30849701 0.93 TSPO (0.86) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL21191657 0.93 TSPO (0.86) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL22345172 0.93 TSPO (0.86) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL30849697 0.93 TSPO (0.86) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL22612467 0.91 TSPO (0.83) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL21191506 0.91 TSPO (0.83) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL22612471 0.91 TSPO (0.83) TSPOGMNNLMNAPOLBCYP3A4
SCHEMBL10524649 0.90 TSPO (0.82) TSPOGMNNLMNAPOLBCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116599005-B Secondary acceleration fault isolation method after direct current breaker failure 天津大学 2024-08-20 — — CN claimed
US-20240251664-A1 LIGHT EMITTING ELEMENT AND AMINE COMPOUND FOR THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2024-07-25 — — US claimed
CN-113078619-B Rapid protection method for flexible direct-current power grid 中国矿业大学 2022-07-15 — — CN claimed
EP-2459220-B1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2020-09-09 — — EP claimed
CN-122081225-A Co-culture cell model of primary glial cells and neurons and culture method — 2026-05-26 — — CN disclosed
US-20260143965-A1 LIGHT EMITTING ELEMENT, AMINE COMPOUND FOR THE LIGHT EMITTING ELEMENT, AND DISPLAY DEVICE INCLUDING THE LIGHT EMITTING ELEMENT SAMSUNG DISPLAY CO LTD (KR) 2026-05-21 — — US disclosed
US-12550426-B2 Semiconductor device SAMSUNG ELECTRONICS CO., LTD. (KR) 2026-02-10 — — US disclosed
US-12545024-B2 Liquid discharge system SEIKO EPSON CORPORATION (JP) 2026-02-10 — — US disclosed
US-20250340883-A1 Method For Treating Cyclophilin B Associated Diseases RESONANCE HEALTH ANALYSIS SERVICES PTY LTD (AU) 2025-11-06 — — US disclosed
US-12437806-B2 Semiconductor device and operating method thereof TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (TW) 2025-10-07 — — US disclosed
US-12404293-B2 Method for producing glycan, building block for gylican synthesis, and compound NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY (JP) 2025-09-02 — — US disclosed
US-12368388-B2 Layout method for power supplies with three-phase integrated transformer and synchronous rectification AA Power Inc. (US) 2025-07-22 — — US disclosed
US-20160257739-A1 PROTECTING GROUP COMPRISING A PURIFICATION TAG ASCENDIS PHARMA A/S (DK) 2016-09-08 — — US disclosed
EP-3054981-A1 PROTECTING GROUP COMPRISING A PURIFICATION TAG Ascendis Pharma A/S (DK) 2016-08-17 — — EP disclosed
US-20150258205-A1 Hydrogel Prodrugs ASCENDIS PHARMA GMBH (DE) 2015-09-17 — — US disclosed
EP-2906617-A1 HYDROGEL PRODRUGS Ascendis Pharma A/S (DK) 2015-08-19 — — EP disclosed
WO-2015052155-A1 PROTECTING GROUP COMPRISING A PURIFICATION TAG ASCENDIS PHARMA A/S (DK) 2015-04-16 — — WO disclosed
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels ASCENDIS PHARMA A/S (DK) 2012-06-21 — — US disclosed
EP-2459220-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS Ascendis Pharma A/S (DK) 2012-06-06 — — EP disclosed
WO-2011012715-A1 BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS ASCENDIS PHARMA AS (DK) 2011-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12545024-B2 Liquid discharge system EXOSC9, EXOSC4, F5 TSPO 4659/4885GMNN 1688/4885LMNA 3301/4885
US-12550426-B2 Semiconductor device LASP1, MTREX, DCX TSPO 3187/4885GMNN 2043/4885LMNA 4214/4885
US-20120156259-A1 Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels PLG, PHYKPL, PLOD3 TSPO 3474/4885GMNN 2440/4885LMNA 3156/4885
US-20160257739-A1 PROTECTING GROUP COMPRISING A PURIFICATION TAG GSTA2, GSTP1, MLN TSPO 752/4885GMNN 873/4885LMNA 1768/4885
US-12404293-B2 Method for producing glycan, building block for gylican synthesis, and compound OSTC, GYPA, AGL TSPO 3711/4885GMNN 131/4885LMNA 1529/4885
US-20150258205-A1 Hydrogel Prodrugs CD44, DNPH1, PHYKPL TSPO 686/4885GMNN 888/4885LMNA 3876/4885
US-20260143965-A1 LIGHT EMITTING ELEMENT, AMINE COMPOUND FOR THE LIGHT EMITTING ELEMENT, AND DISPLAY DEVICE INCLUDING THE LIGHT EMITTING ELEMENT NR2E3, NR2E1, NR0B2 TSPO 4045/4885GMNN 3959/4885LMNA 1640/4885
US-20240251664-A1 LIGHT EMITTING ELEMENT AND AMINE COMPOUND FOR THE SAME NES, NFE2L2, NUCB2 TSPO 2950/4885GMNN 815/4885LMNA 193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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