Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | ACR | P10323 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL5196110 | 0.79 | SLC1A3 (0.53) | CYP2D6MAPK1ALDH1A1KMT2ACYP1A2 | |
| Glutamic Acid SCHEMBL1873097 | 0.79 | SLC1A3 (0.53) | CYP2D6MAPK1ALDH1A1KMT2ACYP1A2 | |
| D-Glutamate SCHEMBL5196106 | 0.79 | SLC1A3 (0.53) | CYP2D6MAPK1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL7815656 | 0.78 | POLB (0.43) | CYP2D6MAPK1ALDH1A1KMT2ACYP1A2 | |
| Succinic Acid SCHEMBL27928187 | 0.77 | KMT2A (0.53) | CYP2D6MAPK1ALDH1A1KDM4EKMT2A | |
| Succinic Acid SCHEMBL11462893 | 0.77 | KMT2A (0.53) | CYP2D6MAPK1ALDH1A1KDM4EKMT2A | |
| Succinic Acid SCHEMBL27928188 | 0.77 | KMT2A (0.53) | CYP2D6MAPK1ALDH1A1KDM4EKMT2A | |
| Beta-Alanine SCHEMBL18230715 | 0.76 | CYP2D6 (0.49) | CYP2D6MAPK1ALDH1A1KDM4EKMT2A | |
| Isoamylamine SCHEMBL16971287 | 0.76 | CYP2D6 (0.46) | CYP2D6MAPK1ALDH1A1KDM4EKMT2A | |
| Adipic Acid SCHEMBL5313716 | 0.76 | ALDH1A1 (0.50) | MAPK1ALDH1A1KDM4EKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1676556-B1 | Cosmetic composition containing a polyorganosiloxane polymer | OREAL (FR) | 2012-01-11 | — | — | EP | disclosed |
| US-20110189117-A1 | COSMETIC COMPOSITION CONTAINING A POLYORGANISILOXANE POLYMER | L'OREAL (FR) | 2011-08-04 | — | — | US | disclosed |
| US-7879316-B2 | Mixture of polyamide-siloxane copolymer in volatile oil; cosmetics | L'OREAL (FR) | 2011-02-01 | — | — | US | disclosed |
| US-7803356-B2 | Compositions containing at least one silicone resin and a volatile non-cyclic silicone oil | L'OREAL (FR) | 2010-09-28 | — | — | US | disclosed |
| US-7758848-B2 | Cosmetic composition containing a polyorganosiloxane polymer | L'OREAL (FR) | 2010-07-20 | — | — | US | disclosed |
| EP-1676556-A2 | Cosmetic composition containing a polyorganosiloxane polymer | L'OREAL (FR) | 2006-07-05 | — | — | EP | disclosed |
| US-20060110345-A1 | Cosmetic composition containing a polyorganosiloxane polymer | L'OREAL (FR) | 2006-05-25 | — | — | US | disclosed |
| US-20050158260-A1 | Cosmetic composition containing a polyorganosiloxane polymer | L'OREAL (FR) | 2005-07-21 | — | — | US | disclosed |
| US-20050142089-A1 | Compositions containing at least one silicone resin and a volatile non-cyclic silicone oil | L'OREL (FR) | 2005-06-30 | — | — | US | disclosed |
| US-20040223987-A1 | Composition structured with a polymer containing a heteroatom and organogelator | L'OREAL S.A. (FR) | 2004-11-11 | — | — | US | disclosed |
| US-20040170586-A1 | Cosmetic composition containing a polyorganosiloxane polymer | L'OREAL (FR) | 2004-09-02 | — | — | US | disclosed |
| EP-1294342-A2 | COMPOSITION STRUCTURED WITH A POLYMER CONTAINING AHETEROATOM AND AN ORGANOGELATOR | L'OREAL (FR) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002055030-A2 | COMPOSITION STRUCTURED WITH A POLYMER CONTAINING A HETEROATOM AND ORGANOGELATOR | OREAL (FR) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050142089-A1 | Compositions containing at least one silicone resin and a volatile non-cyclic silicone oil | RXRA, REV1, RXRG | CYP2D6 4715/4885MAPK1 3349/4885ALDH1A1 4295/4885 |
| US-20040223987-A1 | Composition structured with a polymer containing a heteroatom and organogelator | CUTA, PARG, FABP4 | CYP2D6 1090/4885MAPK1 4790/4885ALDH1A1 1802/4885 |
| US-20040170586-A1 | Cosmetic composition containing a polyorganosiloxane polymer | CUTA, XPA, PRDX1 | CYP2D6 1796/4885MAPK1 4476/4885ALDH1A1 435/4885 |
| US-20110189117-A1 | COSMETIC COMPOSITION CONTAINING A POLYORGANISILOXANE POLYMER | CUTA, PRDX1, PRXL2A | CYP2D6 1091/4885MAPK1 4520/4885ALDH1A1 341/4885 |
| US-20060110345-A1 | Cosmetic composition containing a polyorganosiloxane polymer | CUTA, MITF, SQLE | CYP2D6 3596/4885MAPK1 4298/4885ALDH1A1 2403/4885 |
| US-20050158260-A1 | Cosmetic composition containing a polyorganosiloxane polymer | SQLE, CUTA, FDFT1 | CYP2D6 1624/4885MAPK1 4082/4885ALDH1A1 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.