SCHEMBL1244985

SCHEMBL1244985

O=Cc1cnn(Cc2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.57
PSD A5PKW4 1/20 0.56
HDAC2 Q92769 2/20 0.51
CREBBP Q92793 4/20 0.48
SMN1; SMN2 Q16637 3/20 0.45
POLB P06746 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
NCOR2 Q9Y618 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
CYP19A1 P11511 1/20 0.43
HSD17B10 Q99714 1/20 0.43
LMNA P02545 3/20 0.43
MAPT P10636 1/20 0.43
ADORA2A P29274 1/20 0.43
ADORA1 P30542 1/20 0.43
ALDH1A1 P00352 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18616337 0.91 L3MBTL1 (0.59) L3MBTL1PSDHDAC2CREBBPSMN1; SMN2
SCHEMBL20658807 0.87 L3MBTL1 (0.55) L3MBTL1PSDHDAC2CREBBPSMN1; SMN2
SCHEMBL17591714 0.85 HSD17B10 (0.49) L3MBTL1PSDHDAC2SMN1; SMN2POLB
SCHEMBL12258556 0.84 HDAC2 (0.53) L3MBTL1PSDHDAC2CREBBPSMN1; SMN2
SCHEMBL4769322 0.83 SMN1; SMN2 (0.51) L3MBTL1PSDSMN1; SMN2POLBNPC1
SCHEMBL1245198 0.83 HDAC2 (0.53) L3MBTL1PSDHDAC2CREBBPADORA2A
SCHEMBL30755398 0.83 LMNA (0.58) PSDHDAC2CREBBPSMN1; SMN2TDP1
SCHEMBL20658827 0.83 HSD17B10 (0.67) L3MBTL1PSDHDAC2SMN1; SMN2POLB
SCHEMBL18586165 0.82 VDR (0.48) PSDRAB9ACYP19A1
SCHEMBL17094884 0.82 MEN1 (0.49) L3MBTL1PSDHDAC2CREBBPPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600717-B2 Tricyclic compounds as inhibitors of KRAS INCYTE CORPORATION (US) 2026-04-14 US disclosed
US-12428425-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use AMGEN INC. (US) 2025-09-30 US disclosed
EP-4616913-A2 GCN2 INHIBITORS AND USES THEREOF Merck Patent GmbH (DE) 2025-09-17 EP disclosed
EP-3746075-B1 GCN2 INHIBITORS AND USES THEREOF MERCK PATENT GMBH (DE) 2025-09-03 EP disclosed
EP-4562015-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME Cedilla Therapeutics, Inc. (US) 2025-06-04 EP disclosed
US-20250059190-A1 GCN2 INHIBITORS AND USES THEREOF MERCK PATENT GMBH (DE) 2025-02-20 US disclosed
US-20240309003-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. (US) 2024-09-19 US disclosed
US-12084438-B2 GCN2 inhibitors and uses thereof MERCK PATENT GMBH (DE) 2024-09-10 US disclosed
US-20240182477-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. 2024-06-06 US disclosed
EP-4370515-A1 TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS Incyte Corporation (US) 2024-05-22 EP disclosed
US-20080004327-A1 FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE SEPRACOR INC. (US) 2008-01-03 US disclosed
CN-1890241-A A2BAdenosine receptor antagonists CV THERAPEUTICS INC (US) 2007-01-03 CN disclosed
EP-1678181-A2 A2B ADENOSINE RECEPTOR ANTAGONISTS CV THERAPEUTICS, INC. (US) 2006-07-12 EP disclosed
US-20050119287-A1 A2B adenosine receptor antagonists GILEAD PALO ALTO, INC. 2005-06-02 US disclosed
WO-2005042534-A2 A2B ADENOSINE RECEPTOR ANTAGONISTS CV THERAPEUTICS, INC. (US) 2005-05-12 WO disclosed
US-20020156081-A1 Pyrazolopyrimidines as therapeutic agents ABBOTT LABORATORIES (US) 2002-10-24 US disclosed
EP-0192060-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1986-08-27 EP disclosed
US-4151293-A MITICIDES ABBOTT LABORATORIES (US) 1979-04-24 US disclosed
US-4125530-A FROM 1,1-DIHALO-3,3,3-TRIFLUOROACETONE, BASE, AMMONIA AND A CARBOXALDEHYDE MERCK & CO., INC. (US) 1978-11-14 US disclosed
US-4032522-A ANTI-GOUT, ANTI-HYPERURICEMIC MERCK & CO., INC. (US) 1977-06-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600717-B2 Tricyclic compounds as inhibitors of KRAS KRAS, NRAS, HRAS L3MBTL1 1841/4885PSD 3474/4885HDAC2 2789/4885
US-12428425-B2 Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use MSR1, FPR2, CD14 L3MBTL1 4809/4885PSD 1111/4885HDAC2 3246/4885
US-20050119287-A1 A2B adenosine receptor antagonists ADORA2B, ADORA2A, ADORA3 L3MBTL1 2622/4885PSD 4317/4885HDAC2 898/4885
US-20240309003-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 L3MBTL1 4809/4885PSD 1111/4885HDAC2 3246/4885
US-12084438-B2 GCN2 inhibitors and uses thereof EIF2AK4, GCN1, GCGR L3MBTL1 2553/4885PSD 4107/4885HDAC2 488/4885
US-20240182477-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 L3MBTL1 4809/4885PSD 1111/4885HDAC2 3246/4885
US-20250059190-A1 GCN2 INHIBITORS AND USES THEREOF EIF2AK4, GCN1, GCGR L3MBTL1 2553/4885PSD 4107/4885HDAC2 488/4885
US-20020156081-A1 Pyrazolopyrimidines as therapeutic agents DPYD, CYP2D6, UGT1A1 L3MBTL1 3386/4885PSD 3941/4885HDAC2 674/4885
US-20080004327-A1 FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE DAO, DDO, AOX1 L3MBTL1 2103/4885PSD 1950/4885HDAC2 3068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.