Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898362 | 0.89 | METAP2 (0.75) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL8129 | 0.89 | METAP2 (0.75) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL9551658 | 0.88 | METAP2 (0.74) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Biphenyl SCHEMBL9323135 | 0.84 | METAP2 (0.68) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL2552868 | 0.83 | METAP2 (0.66) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL8503660 | 0.81 | METAP2 (0.63) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| SCHEMBL20658108 | 0.80 | METAP2 (0.61) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL15263951 | 0.77 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL17959149 | 0.77 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 | |
| Fumagillin SCHEMBL6953272 | 0.77 | METAP2 (1.00) | METAP2ABCB11LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11812950-B2 | Tapered looped suture | COVIDIEN LP (US) | 2023-11-14 | — | — | US | disclosed |
| US-20230309990-A1 | COMPOUND BARB MEDICAL DEVICE AND METHOD | COVIDIEN LP | 2023-10-05 | — | — | US | disclosed |
| EP-3053531-B1 | COMPOUND BARB MEDICAL DEVICE | COVIDIEN LP (US) | 2023-08-09 | — | — | EP | disclosed |
| US-11660088-B2 | Compound barb medical device and method | COVIDIEN LP (US) | 2023-05-30 | — | — | US | disclosed |
| US-20210145436-A1 | TAPERED LOOPED SUTURE | COVIDIEN LP | 2021-05-20 | — | — | US | disclosed |
| US-10912552-B2 | Tapered looped suture | COVIDIEN LP (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200345351-A1 | COMPOUND BARB MEDICAL DEVICE AND METHOD | TYCO HEALTHCARE GROUP LP | 2020-11-05 | — | — | US | disclosed |
| US-10729429-B2 | Compound barb medical device and method | COVIDIEN LP (US) | 2020-08-04 | — | — | US | disclosed |
| EP-2446837-B1 | Wound closure device including barbed pins | COVIDIEN LP (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-2289428-B1 | Compound barb medical device and method | COVIDIEN LP (US) | 2019-08-14 | — | — | EP | disclosed |
| EP-2163207-A1 | Tapered looped suture | Tyco Healthcare Group LP (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20100063540-A1 | TAPERED LOOPED SUTURE | TYCO HEALTHCARE GROUP LP | 2010-03-11 | — | — | US | disclosed |
| EP-2103260-A1 | Bioactive substance in a barbed suture | Tyco Healthcare Group LP (US) | 2009-09-23 | — | — | EP | disclosed |
| EP-2092895-A1 | Compound barb medical device and method | Tyco Healthcare Group LP (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20090210006-A1 | COMPOUND BARB MEDICAL DEVICE AND METHOD | TYCO HEALTHCARE GROUP LP | 2009-08-20 | — | — | US | disclosed |
| EP-1897500-B1 | Barbed sutures | TYCO HEALTHCARE (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090076543-A1 | Method of Forming Barbs on a Suture | TYCO HEALTHCARE GROUP LP | 2009-03-19 | — | — | US | disclosed |
| EP-2036502-A2 | Method of forming barbs on a suture | Tyco Healthcare Group LP (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-1897500-A1 | Barbed sutures | Tyco Healthcare Group, LP (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20080058869-A1 | Bioactive substance in a barbed suture | COVIDIEN LP | 2008-03-06 | — | — | US | disclosed |