SCHEMBL12494043

SCHEMBL12494043

COc1ccc(C2CC(c3ccccc3)=NN2c2ccc(S(N)(=O)=O)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 13/20 1.00
▸ KDM4E B2RXH2 5/20 1.00
▸ ALDH1A1 P00352 5/20 1.00
▸ MAPT P10636 5/20 1.00
▸ GAA P10253 4/20 1.00
▸ GLA P06280 3/20 1.00
▸ ATM Q13315 2/20 1.00
▸ PDE5A O76074 1/20 1.00
▸ CDC42 P60953 1/20 1.00
▸ NPSR1 Q6W5P4 1/20 1.00
▸ CA1 P00915 4/20 0.92
▸ CA2 P00918 4/20 0.92
▸ PTGS2 P35354 1/20 0.82
▸ CA12 O43570 1/20 0.81
▸ CA9 Q16790 1/20 0.81
▸ MMP2 P08253 1/20 0.80
▸ MMP9 P14780 1/20 0.80
▸ HPGD P15428 2/20 0.79
▸ CFTR P13569 1/20 0.79
▸ GOPC Q9HD26 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15197341 0.96 CA1 (1.00) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL18827569 0.94 PTGS2 (0.92) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL18826382 0.91 L3MBTL1 (0.84) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL5564567 0.89 L3MBTL1 (1.00) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL14484122 0.89 CA1 (1.00) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL15301136 0.89 KDM4E (0.88) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL18826383 0.89 PTGS2 (0.85) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL15197342 0.88 L3MBTL1 (0.78) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL18826375 0.88 CA1 (0.91) L3MBTL1KDM4EALDH1A1MAPTGAA
SCHEMBL18826390 0.87 CA12 (0.80) L3MBTL1KDM4EALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260053804-A1 Compositions and Methods for the Restoration of Ciliary Function UNIV YALE (US) 2026-02-26 — — US claimed
US-12433871-B2 Effects of age-dependent changes in cell size on endothelial cell growth THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) 2025-10-07 — — US claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 — — EP claimed
CN-120193076-A Application of tumor metastasis marker and protein inhibitor and diagnostic reagent 宁波康柏睿格医药科技有限公司 2025-06-24 — — CN claimed
WO-2025033911-A1 METHOD FOR REPROGRAMMING TYPE 1 ALVEOLAR CELLS INTO TYPE 2 ALVEOLAR CELLS USING RHOSIN, DASATINIB, OR ML141, AND COMPOSITION FOR INHIBITING LUNG CANCER METASTASIS CONTAINING ML141 OR DASATINIB 가톨릭대학교 산학협력단 2025-02-13 — — WO claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 — — WO claimed
CN-117982491-A Application of CDC42 protein as acting target in preparation of medicine for treating radioactive liver fibrosis 南方医科大学南方医院 2024-05-07 — — CN claimed
WO-2023196235-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-12 — — WO claimed
US-20230310471-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-05 — — US claimed
WO-2023091964-A2 COMPOSITIONS AND METHODS FOR THE INHIBITION OF TUMOR METASTASIS AND HORIZONTAL GENE TRANSFER THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) 2023-05-25 — — WO claimed
US-20220175730-A1 Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth THE MEDICAL COLLEGE OF WISCONSIN, INC. 2022-06-09 — — US claimed
WO-2026106552-A1 THERAPEUTIC CONVERSION OF CANCER CELLS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2026-05-21 — — WO disclosed
EP-4713688-A2 HUMAN EIF3L BINDING MOLECULES AND CANCER EXOSOME DIAGNOSTICS AND ANTI-THROMBOTIC TREATMENT The Cleveland Clinic Foundation (US) 2026-03-25 — — EP disclosed
US-12569494-B2 Compositions and methods to promote thymic regeneration FRED HUTCHINSON CANCER CENTER (US) 2026-03-10 — — US disclosed
US-20260053804-A1 Compositions and Methods for the Restoration of Ciliary Function UNIV YALE (US) 2026-02-26 — — US disclosed
US-20130345277-A1 Modulators of GTPase and Use In Relevant Treatment Kansas University Center for Technology Commercialization, Inc. (US) 2013-12-26 — — US disclosed
US-20130217744-A1 EFFICACY IN TREATING BACTERIAL INFECTIONS BALL STATE UNIVERSITY 2013-08-22 — — US disclosed
US-20130217744-A1 EFFICACY IN TREATING BACTERIAL INFECTIONS BALL STATE UNIVERSITY 2013-08-22 — — US disclosed
US-20130217744-A1 EFFICACY IN TREATING BACTERIAL INFECTIONS BALL STATE UNIVERSITY 2013-08-22 — — US disclosed
WO-2012125884-A1 DERIVATIVES OF CELECOXIB, USE THEREOF AND PREPARATION THEREOF SOUTHERN RESEARCH INSTITUTE (US) 2012-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130345277-A1 Modulators of GTPase and Use In Relevant Treatment KRAS, CDC42, RHOT2 L3MBTL1 2389/4885KDM4E 4544/4885ALDH1A1 4580/4885
US-12569494-B2 Compositions and methods to promote thymic regeneration CDC42, BMP4, TPMT L3MBTL1 100/4885KDM4E 2577/4885ALDH1A1 4657/4885
US-20220175730-A1 Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth VEGFA, HGF, HDGF L3MBTL1 1647/4885KDM4E 3645/4885ALDH1A1 4016/4885
US-20260053804-A1 Compositions and Methods for the Restoration of Ciliary Function MTCL3, DYNLL2, CEP170 L3MBTL1 1468/4885KDM4E 3839/4885ALDH1A1 4545/4885
US-12433871-B2 Effects of age-dependent changes in cell size on endothelial cell growth VEGFA, HGF, HDGF L3MBTL1 1647/4885KDM4E 3645/4885ALDH1A1 4016/4885
US-20130217744-A1 EFFICACY IN TREATING BACTERIAL INFECTIONS CDC42, RAC1, CDC42BPG L3MBTL1 1907/4885KDM4E 4262/4885ALDH1A1 4864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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