Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | LDHB | P07195 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499265 | 0.86 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2POLB | |
| SCHEMBL12499862 | 0.85 | PLA2G2A (0.45) | KDM4EMAPTKMT2ALMNASMN1; SMN2 | |
| SCHEMBL12499672 | 0.85 | RNASEH1 (0.43) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL12499272 | 0.84 | HCAR2 (0.45) | MAPTKMT2ALMNASMN1; SMN2MEN1 | |
| SCHEMBL12498729 | 0.82 | SRD5A2 (0.46) | LMNALDHALDHBPOLBNPC1 | |
| SCHEMBL12499378 | 0.81 | MAPT (0.40) | VDRKDM4EMAPTKMT2ALMNA | |
| SCHEMBL12499324 | 0.81 | MAPT (0.40) | VDRKDM4EMAPTKMT2ALMNA | |
| SCHEMBL12499850 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2 | |
| SCHEMBL23142706 | 0.75 | CYP1A2 (0.51) | KDM4EMAPTKMT2ALMNASMN1; SMN2 | |
| SCHEMBL3718927 | 0.73 | ALDH1A1 (0.47) | KDM4EMAPTKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |