Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499736 | 0.88 | SRD5A2 (0.46) | KMT2AMEN1LMNAPOLB | |
| SCHEMBL12499826 | 0.86 | CCR2 (0.39) | — | |
| SCHEMBL12499705 | 0.85 | HCAR2 (0.42) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL12498738 | 0.84 | MAPT (0.47) | MAPTKDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12499400 | 0.81 | VDR (0.49) | MAPTVDRKDM4EKMT2AMEN1 | |
| SCHEMBL12499324 | 0.80 | MAPT (0.40) | MAPTVDRKDM4EKMT2AMEN1 | |
| SCHEMBL12498747 | 0.79 | AADAT (0.43) | MAPTKMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL2087514 | 0.76 | PKM (0.34) | MAPTKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL12498729 | 0.75 | SRD5A2 (0.46) | LMNAPOLB | |
| SCHEMBL12499879 | 0.73 | MAPT (0.46) | MAPTKDM4EKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |