Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499672 | 0.86 | RNASEH1 (0.43) | MAPTFPR2PROKR1KMT2AGAA | |
| SCHEMBL12499862 | 0.86 | PLA2G2A (0.45) | MAPTSMN1; SMN2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL12498726 | 0.84 | HSP90AA1 (0.47) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL12498677 | 0.81 | PLA2G2A (0.45) | MAPTSMN1; SMN2ALDH1A1KMT2AGAA | |
| SCHEMBL3718927 | 0.81 | ALDH1A1 (0.47) | TSHRMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL12499839 | 0.78 | LMNA (0.43) | MAPTALDH1A1KMT2AGAAKDM4E | |
| SCHEMBL12499851 | 0.77 | ALDH1A1 (0.43) | MAPTSMN1; SMN2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL12498769 | 0.77 | GPR52 (0.44) | MAPTSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL12499589 | 0.75 | ALOX5 (0.43) | TSHRMAPTSMN1; SMN2NOTUMALDH1A1 | |
| SCHEMBL12499826 | 0.72 | CCR2 (0.39) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103071-A2 | COMPOUNDS AND COMPOSITIONS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-08-02 | — | — | WO | disclosed |