Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156703 | 0.85 | HRH3 (0.57) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13713488 | 0.81 | L3MBTL1 (0.53) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL24306041 | 0.81 | RAB9A (0.54) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13713514 | 0.81 | L3MBTL1 (0.53) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL10311684 | 0.81 | HTT (0.64) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4424813 | 0.80 | MEN1 (0.52) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13915565 | 0.80 | RAB9A (0.53) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3716649 | 0.79 | L3MBTL1 (0.64) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2159850 | 0.79 | TSHR (0.44) | ALDH1A1SMN1; SMN2L3MBTL1HTTCYP1A2 | |
| SCHEMBL48652 | 0.79 | HRH3 (0.61) | TAS1R3TAS1R1ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180147163-A1 | COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS | HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2018-05-31 | — | — | US | claimed |
| EP-3297676-A2 | COMBINATION OF TRPM8-AGONIST AND NACHR-AGONIST FOR TREATMENT OF OBESITY AND RELATED DISORDERS AND FOR WEIGHT REDUCTION | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2018-03-28 | — | — | EP | claimed |
| WO-2016188932-A2 | COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-12-01 | — | — | WO | claimed |
| US-20100035938-A1 | Cooling Compounds | GIVAUDAN SA (CH) | 2010-02-11 | — | — | US | claimed |
| US-11059783-B2 | Pyridinyl cyclohexanecarboxamide cooling compounds | GIVAUDAN S.A. (CH) | 2021-07-13 | — | — | US | disclosed |
| US-10568852-B2 | Combination compositions and their use in methods for treating obesity and obesity-related disorders | HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2020-02-25 | — | — | US | disclosed |
| US-20190194134-A1 | PYRIDINYL CYCLOHEXANECARBOXAMIDE COOLING COMPOUNDS | GIVAUDAN S.A. (CH) | 2019-06-27 | — | — | US | disclosed |
| US-10221136-B2 | Pyridinyl cyclohexanecarboxamide cooling compounds | Givaudan, S.A. (CH) | 2019-03-05 | — | — | US | disclosed |
| US-20180147163-A1 | COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS | HELMHOLTZ ZENTRUM MUNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2018-05-31 | — | — | US | disclosed |
| EP-3297676-A2 | COMBINATION OF TRPM8-AGONIST AND NACHR-AGONIST FOR TREATMENT OF OBESITY AND RELATED DISORDERS AND FOR WEIGHT REDUCTION | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2018-03-28 | — | — | EP | disclosed |
| US-20170008845-A1 | PYRIDINYL CYCLOHEXANECARBOXAMIDE COOLING COMPOUNDS | GIVAUDAN SA (CH) | 2017-01-12 | — | — | US | disclosed |
| WO-2016188932-A2 | COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-12-01 | — | — | WO | disclosed |
| WO-2012054528-A2 | CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES | ELCELYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| US-7880011-B2 | reacting p-menthanecarboxamide in toluene with 2-vinyl pyridine, 18-crown-6 chelating agent , potassium tert-butoxide (20% in tetrahydrofuran), heating to produce N-(2-pyridin-2-ylethyl)p-menthanecarboxamide[(1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)cyclohexanecarboxamide | Givandan, S.A. (CH) | 2011-02-01 | — | — | US | disclosed |
| EP-2178836-A1 | AMIDE ADDITION REACTION | Givaudan SA (CH) | 2010-04-28 | — | — | EP | disclosed |
| US-20100035938-A1 | Cooling Compounds | GIVAUDAN SA (CH) | 2010-02-11 | — | — | US | disclosed |
| WO-2009012609-A1 | AMIDE ADDITION REACTION | GIVAUDAN SA (CH) | 2009-01-29 | — | — | WO | disclosed |
| US-20090030042-A1 | Amide Addition Reaction | GIVAUDAN, SA. (CH) | 2009-01-29 | — | — | US | disclosed |
| EP-1917074-A1 | COOLING COMPOUNDS | Givaudan SA (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007019719-A1 | COOLING COMPOUNDS | GIVAUDAN SA (CH) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059783-B2 | Pyridinyl cyclohexanecarboxamide cooling compounds | CBR3, TAS2R31, CTRB2 | TAS1R3 141/4885TAS1R1 80/4885ALDH1A1 1675/4885 |
| US-10568852-B2 | Combination compositions and their use in methods for treating obesity and obesity-related disorders | FABP4, LIPC, GPR119 | TAS1R3 2947/4885TAS1R1 3486/4885ALDH1A1 1132/4885 |
| US-20090030042-A1 | Amide Addition Reaction | HRH2, OGDH, MDH2 | TAS1R3 3216/4885TAS1R1 3524/4885ALDH1A1 2457/4885 |
| US-20180147163-A1 | COMBINATION COMPOSITIONS AND THEIR USE IN METHODS FOR TREATING OBESITY AND OBESITY-RELATED DISORDERS | FABP4, LIPC, GPR119 | TAS1R3 2947/4885TAS1R1 3486/4885ALDH1A1 1132/4885 |
| US-20170008845-A1 | PYRIDINYL CYCLOHEXANECARBOXAMIDE COOLING COMPOUNDS | CBR3, CTRB2, TAS2R31 | TAS1R3 127/4885TAS1R1 79/4885ALDH1A1 1603/4885 |
| US-10221136-B2 | Pyridinyl cyclohexanecarboxamide cooling compounds | CBR3, CTRB2, TAS2R31 | TAS1R3 127/4885TAS1R1 79/4885ALDH1A1 1603/4885 |
| US-20100035938-A1 | Cooling Compounds | EBP, HRH1, TAS2R42 | TAS1R3 134/4885TAS1R1 63/4885ALDH1A1 945/4885 |
| US-20190194134-A1 | PYRIDINYL CYCLOHEXANECARBOXAMIDE COOLING COMPOUNDS | CBR3, TAS2R31, CTRB2 | TAS1R3 141/4885TAS1R1 80/4885ALDH1A1 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.