Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.62 |
| ▸ | IGF1R | P08069 | 2/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | TYR | P14679 | 1/20 | 0.57 |
| ▸ | CCR5 | P51681 | 3/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21203290 | 0.93 | IAPP (0.72) | IAPPALOX15IGF1RALOX5CYP19A1 | |
| Didemethyltetrahydrocurcumin SCHEMBL6344877 | 0.93 | IAPP (0.73) | IAPPALOX15IGF1RALOX5OR51E2 | |
| Letestuianin C SCHEMBL4410123 | 0.87 | F2RL1 (0.60) | ALOX5OR51E2CYP19A1KDM4EMEN1 | |
| SCHEMBL28165571 | 0.85 | IAPP (0.82) | IAPPALOX15IGF1RALOX5OR51E2 | |
| SCHEMBL9360095 | 0.85 | IAPP (0.87) | IAPPALOX15ALOX5OR51E2CYP19A1 | |
| SCHEMBL28349297 | 0.85 | IAPP (0.84) | IAPPALOX15ALOX5OR51E2CYP19A1 | |
| SCHEMBL12601803 | 0.84 | ALOX5 (0.52) | IAPPALOX15IGF1RALOX5OR51E2 | |
| Tetrahydrodemethoxycurcumin SCHEMBL29565582 | 0.82 | ALOX5 (0.89) | ALOX5OR51E2MEN1LMNACYP1A2 | |
| Tetrahydrodemethoxycurcumin SCHEMBL4413210 | 0.82 | ALOX5 (0.89) | ALOX5OR51E2MEN1LMNACYP1A2 | |
| SCHEMBL3217413 | 0.81 | BACE1 (0.53) | ALOX5OR51E2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680143-B2 | Orally active curcuminoid compounds | LAILA PHARMACEUTICALS PVT. LTD. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8680143-B2 | Orally active curcuminoid compounds | LAILA PHARMACEUTICALS PVT. LTD. (US) | 2014-03-25 | — | — | US | disclosed |
| US-8568802-B2 | Process for producing enriched fractions of tetrahydroxycurcumin and tetrahydrotetrahydroxy-curcumin from the extracts of Curcuma longa | LAILA IMPEX (US) | 2013-10-29 | — | — | US | disclosed |
| US-8568802-B2 | Process for producing enriched fractions of tetrahydroxycurcumin and tetrahydrotetrahydroxy-curcumin from the extracts of Curcuma longa | LAILA IMPEX (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110112190-A1 | ORALLY ACTIVE CURCUMINOID COMPOUNDS | LAILA PHARMACEUTICALS PVT. LTD. (IN) | 2011-05-12 | — | — | US | disclosed |
| US-20110112190-A1 | ORALLY ACTIVE CURCUMINOID COMPOUNDS | LAILA PHARMACEUTICALS PVT. LTD. (IN) | 2011-05-12 | — | — | US | disclosed |
| US-20100168248-A1 | PROCESS FOR PRODUCING ENRICHED FRACTIONS OF TETRAHYDROXYCURCUMIN AND TETRAHYDROTETRAHDROXY-CURCUMIN FROM THE EXTRACTS OF CURCUMA LONGA | LAILA IMPEX (IN) | 2010-07-01 | — | — | US | disclosed |
| US-20100168248-A1 | PROCESS FOR PRODUCING ENRICHED FRACTIONS OF TETRAHYDROXYCURCUMIN AND TETRAHYDROTETRAHDROXY-CURCUMIN FROM THE EXTRACTS OF CURCUMA LONGA | LAILA IMPEX (IN) | 2010-07-01 | — | — | US | disclosed |
| WO-2010004579-A2 | ORALLY ACTIVE CURCUMINOID COMPOUNDS | LAILA PHARMACEUTICALS PVT. LTD. (IN) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168248-A1 | PROCESS FOR PRODUCING ENRICHED FRACTIONS OF TETRAHYDROXYCURCUMIN AND TETRAHYDROTETRAHDROXY-CURCUMIN FROM THE EXTRACTS OF CURCUMA LONGA | HMOX1, HMOX2, HPD | IAPP 4028/4885ALOX15 180/4885IGF1R 4568/4885 |
| US-20110112190-A1 | ORALLY ACTIVE CURCUMINOID COMPOUNDS | ALOX12, ALOX15, ALOX15B | IAPP 2851/4885ALOX15 2/4885IGF1R 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.