Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL372248 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL372162 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL372249 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL126073 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL5311584 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL372318 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL28984157 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL372317 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL372405 | 1.00 | CA4 (0.84) | CA4ALDH1A1CASP1FAHD1 | |
| Citric Acid SCHEMBL23118547 | 0.97 | CA4 (0.80) | CA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1728 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260123659-A1 | NUTRITIONAL FORMULA | BUILDING BLOCK NUTRITIONALS LLC (US) | 2026-05-07 | — | — | US | claimed |
| US-12603390-B2 | Separator for nonaqueous electrolyte secondary battery, and nonaqueous electrolyte secondary battery | PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD. (JP) | 2026-04-14 | — | — | US | claimed |
| US-12594448-B2 | Environmentally-clean aqueous-based fire extinguishing biochemical liquid concentrates for mixing with proportioned quantities of water to produce fire extinguishing water streams | MIGHTY FIRE BREAKER LLC (US) | 2026-04-07 | — | — | US | claimed |
| US-20260090985-A1 | ORAL MUCOSAL FORMULATIONS OF ASPIRIN | ASPIRE BIOPHARMA HOLDINGS INC (US) | 2026-04-02 | — | — | US | claimed |
| EP-4687486-A1 | NOVEL COMBINATIONS COMPRISING KONJAC MANNAN, THEIR COMPOSITIONS AND USES THEREOF | Vivatis Pharma GmbH (DE) | 2026-02-11 | — | — | EP | claimed |
| EP-4687485-A1 | NOVEL COMBINATIONS COMPRISING KONJAC MANNAN, THEIR COMPOSITIONS AND USES THEREOF | Vivatis Pharma GmbH (DE) | 2026-02-11 | — | — | EP | claimed |
| US-20260014403-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS | MIGHTY FIRE BREAKER LLC (US) | 2026-01-15 | — | — | US | claimed |
| US-20260014404-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | PERIMETER SOLUTIONS, LP (US) | 2026-01-15 | — | — | US | claimed |
| WO-2025264733-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | PERIMETER SOLUTIONS, LP (US) | 2025-12-26 | — | — | WO | claimed |
| EP-4404916-B1 | AN IMPROVED PHARMACEUTICAL COMPOSITION FOR NASAL USE, PREPARATION, AND USE THEREOF | JADRAN GALENSKI LABORATORIJ D D (HR) | 2025-08-06 | — | — | EP | claimed |
| EP-0517869-B1 | Hydraulic binder and process for its manufacture | HOLDERBANK FINANC GLARUS (CH) | 1998-05-20 | — | — | EP | claimed |
| US-5643675-A | MIXTURES OF THERMOSETTING RESIN, LATENT ACID CATALYST AND ALKALI METAL SALT OF POLYBASIC ACID(AS LIFE EXTENDER), FOR MAKING FOUNDRY CORES OR MOLDS WITH SAND | BORDEN, INC. (US) | 1997-07-01 | — | — | US | claimed |
| EP-0363194-B1 | Device for controlling relative humidity within a substantially sealed container | PHILIP MORRIS PROD (US) | 1996-03-27 | — | — | EP | claimed |
| EP-0653260-A1 | Addition for promotion of bench life extension in a hot box binder system | BORDEN, INC. (US) | 1995-05-17 | — | — | EP | claimed |
| EP-0226332-B1 | VETERINARY COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1992-03-25 | — | — | EP | claimed |
| US-5037459-A | In a sealed container | PHILIP MORRIS MANAGEMENT CORP. (US) | 1991-08-06 | — | — | US | claimed |
| US-5035731-A | Containing bubber | PHILIP MORRIS MANAGEMENT CORP. (US) | 1991-07-30 | — | — | US | claimed |
| EP-0363194-A2 | Device for controlling relative humidity within a substantially sealed container | Philip Morris Products Inc. (US) | 1990-04-11 | — | — | EP | claimed |
| US-4868170-A | ANTIINFLAMMATORY, OXIDATION RESISTANCE | E. R. SQUIBB & SONS, INC. (US) | 1989-09-19 | — | — | US | claimed |
| US-3962106-A | DETERGENTS | LEVER BROTHERS COMPANY (US) | 1976-06-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12603390-B2 | Separator for nonaqueous electrolyte secondary battery, and nonaqueous electrolyte secondary battery | TST, CD99, SLC6A12 | CA4 1060/4885ALDH1A1 3873/4885CASP1 4186/4885 |
| US-12594448-B2 | Environmentally-clean aqueous-based fire extinguishing biochemical liquid concentrates for mixing with proportioned quantities of water to produce fire extinguishing water streams | CS, CA3, CA1 | CA4 60/4885ALDH1A1 651/4885CASP1 813/4885 |
| US-20260123659-A1 | NUTRITIONAL FORMULA | FABP2, LPO, LPL | CA4 3722/4885ALDH1A1 3727/4885CASP1 4649/4885 |
| US-20260014404-A1 | LONG-TERM FIRE RETARDANT WITH CORROSION INHIBITORS AND METHODS FOR MAKING AND USING SAME | SLC6A12, SLC11A2, KCNN1 | CA4 443/4885ALDH1A1 4616/4885CASP1 277/4885 |
| US-20260014403-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS | ME1, ATP6V1A, ATP5MF | CA4 47/4885ALDH1A1 308/4885CASP1 1443/4885 |
| US-20260090985-A1 | ORAL MUCOSAL FORMULATIONS OF ASPIRIN | SBDS, CYP2C19, PTGS2 | CA4 2501/4885ALDH1A1 953/4885CASP1 729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.