Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12707406 | 0.86 | TDO2 (0.42) | PTGS2TDO2CYP11B1CYP11B2KMT2A | |
| SCHEMBL12707404 | 0.80 | PLA2G7 (0.44) | PTGS2TDO2CYP11B1CYP11B2RPS6KA3 | |
| SCHEMBL12707335 | 0.79 | TDO2 (0.38) | PTGS2TDO2CYP11B1CYP11B2KMT2A | |
| SCHEMBL20124291 | 0.77 | IDO1 (0.41) | RPS6KA3KMT2AKITIDO1CHUK | |
| SCHEMBL890757 | 0.75 | S100A4 (0.46) | IDO1AGPAT2 | |
| SCHEMBL22907284 | 0.74 | TDO2 (0.41) | PTGS2TDO2CYP11B1CYP11B2KMT2A | |
| SCHEMBL2648933 | 0.74 | NUDT1 (0.42) | RPS6KA3GABRA1GABRA5GABRA3GSK3B | |
| SCHEMBL6222583 | 0.71 | CYP11B1 (0.54) | CYP11B1CYP11B2KMT2A | |
| SCHEMBL527540 | 0.70 | ALDH1A1 (0.39) | PTGS2TDO2CYP11B1CYP11B2RPS6KA3 | |
| SCHEMBL26462975 | 0.70 | SRC (0.47) | PTGS2TDO2CYP11B1CYP11B2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | GABRA5, GABRA3, GABRA2 | PTGS2 1242/4885TDO2 1858/4885CYP11B1 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.