Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527540 | 0.87 | ALDH1A1 (0.39) | PTGS2ALDH1A1ABL1TDO2CASP1 | |
| SCHEMBL12707407 | 0.86 | PLA2G7 (0.49) | PLA2G7PTGS2ALDH1A1ABL1TDO2 | |
| SCHEMBL7085707 | 0.83 | ADRA2B (0.37) | CYP11B1CYP11B2RPS6KA3CYP3A4ADRA2B | |
| SCHEMBL12707403 | 0.80 | PTGS2 (0.40) | PTGS2TDO2CYP11B1CYP11B2RPS6KA3 | |
| SCHEMBL2893826 | 0.77 | PLA2G7 (0.60) | PLA2G7ALDH1A1ABL1TDO2CASP1 | |
| SCHEMBL7086302 | 0.76 | ABL1 (0.44) | PLA2G7PTGS2ALDH1A1ABL1TDO2 | |
| SCHEMBL31607621 | 0.75 | PLA2G7 (0.65) | PLA2G7ALDH1A1CASP1PDE10ACYP3A4 | |
| SCHEMBL8848693 | 0.75 | PLA2G7 (0.65) | PLA2G7ALDH1A1CASP1PDE10ACYP3A4 | |
| SCHEMBL30092397 | 0.75 | PLA2G7 (0.65) | PLA2G7ALDH1A1CASP1PDE10ACYP3A4 | |
| SCHEMBL527609 | 0.74 | ABL1 (0.45) | PTGS2ALDH1A1ABL1TDO2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082147-A1 | SUBSTITUTED IMIDAZOTRIAZINES | GABRA5, GABRA3, GABRA2 | PLA2G7 1779/4885PTGS2 1242/4885ALDH1A1 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.