Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9333256 | 1.00 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL9333564 | 1.00 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL9333587 | 1.00 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL9333535 | 1.00 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL8746586 | 1.00 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL540169 | 1.00 | TSHR (0.41) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL163984 | 0.93 | — | — | |
| SCHEMBL1063406 | 0.87 | ALDH1A1 (0.46) | TSHRALDH1A1TP53HIF1AHSD17B10 | |
| SCHEMBL28555010 | 0.87 | EPHX2 (0.42) | TSHRALDH1A1ABCB11CYP3A4ADRA2B | |
| SCHEMBL7878546 | 0.87 | ALDH1A1 (0.46) | TSHRALDH1A1TP53HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260116857-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS | PARDES BIOSCIENCES INC (US) | 2026-04-30 | — | — | US | disclosed |
| US-20250122219-A1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. | 2025-04-17 | — | — | US | disclosed |
| WO-2025080863-A1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2025-04-17 | — | — | WO | disclosed |
| US-12145911-B2 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2024-11-19 | — | — | US | disclosed |
| US-20240270693-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2024-08-15 | — | — | US | disclosed |
| EP-3762386-B1 | ADENOSINE RECEPTOR ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS INC (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-116685576-A | Cysteine protease inhibitors and methods of use thereof | 美商帕迪斯生物科学公司 | 2023-09-01 | — | — | CN | disclosed |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| EP-4161902-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | Pardes Biosciences, Inc. (US) | 2022-12-13 | — | — | US | disclosed |
| EP-1189928-A1 | METHODS AND COMPOSITIONS FOR CONTROLLED POLYPEPTIDE SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-03-27 | — | — | EP | disclosed |
| US-20020032309-A1 | Methods and compositions for controlled polypeptide synthesis | NATIONAL SCIENCE FOUNDATION | 2002-03-14 | — | — | US | disclosed |
| WO-2001094379-A2 | METHODS AND COMPOSITIONS FOR CONTROLLED SYNTHESIS OF AMINO ACID POLYMERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-12-13 | — | — | WO | disclosed |
| WO-2000068252-A1 | METHODS AND COMPOSITIONS FOR CONTROLLED POLYPEPTIDE SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-11-16 | — | — | WO | disclosed |
| US-5753652-A | Antiretroviral hydrazine derivatives | NOVARTIS CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |
| US-5350839-A | Esters to improve taste and remove bitterness | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1994-09-27 | — | — | US | disclosed |
| EP-0553353-A1 | 2'-MODIFIED ERYTHROMYCIN OR DERIVATIVE THEREOF | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-4764523-A | Novel carbonic acid esters | CIBA-GEIGY CORPORATION (US) | 1988-08-16 | — | — | US | disclosed |
| US-4017503-A | Antifungal 1-substituted benzimidazoles | MERCK & CO., INC. (US) | 1977-04-12 | — | — | US | disclosed |
| US-3998816-A | 7-[5-N-(n-Butoxyethoxy carbonyl and 2-chloroethoxy carbonyl)-amino] cephalosporins C | MEIJI SEIKA KAISHA, LTD. (JA) | 1976-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260116857-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOFS | CTRC, CTRL, CTSL | TSHR 2799/4885ALDH1A1 3293/4885TP53 905/4885 |
| US-20250122219-A1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF | SDHA, SDHB, DPYD | TSHR 4706/4885ALDH1A1 684/4885TP53 336/4885 |
| US-20240270693-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSV, CTSL | TSHR 4585/4885ALDH1A1 2252/4885TP53 237/4885 |
| US-20020032309-A1 | Methods and compositions for controlled polypeptide synthesis | NGLY1, LNPEP, NPPA | TSHR 3552/4885ALDH1A1 4856/4885TP53 2399/4885 |
| US-12145911-B2 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | TSHR 4585/4885ALDH1A1 2252/4885TP53 237/4885 |
| US-11524940-B1 | Inhibitors of cysteine proteases and methods of use thereof | CTRL, CTSV, CTSL | TSHR 4585/4885ALDH1A1 2252/4885TP53 237/4885 |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | TSHR 4669/4885ALDH1A1 1863/4885TP53 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.