Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 9/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520454 | 0.80 | DYRK1A (0.47) | DYRK1ATYMS | |
| SCHEMBL21161374 | 0.79 | TYMS (0.49) | TYMS | |
| SCHEMBL12884842 | 0.79 | TYMS (0.46) | DYRK1ATYMS | |
| SCHEMBL15061831 | 0.79 | TYMS (0.48) | DYRK1ATYMS | |
| SCHEMBL7011689 | 0.79 | ATAD2 (0.38) | TYMS | |
| SCHEMBL24704369 | 0.79 | DYRK1A (0.46) | DYRK1ATYMS | |
| SCHEMBL3391755 | 0.78 | DYRK1A (0.42) | DYRK1ATYMS | |
| SCHEMBL3793648 | 0.78 | DYRK1A (0.42) | DYRK1ATYMS | |
| SCHEMBL166747 | 0.76 | TYMS (0.49) | TYMS | |
| SCHEMBL14453489 | 0.76 | TYMS (0.47) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728282-B1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-11-22 | — | — | EP | disclosed |
| EP-4234566-A1 | MODIFIED NUCLEOSIDE OR NUCLEOTIDE | BGI Shenzhen (CN) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022083686-A1 | MODIFIED NUCLEOSIDE OR NUCLEOTIDE | 深圳华大生命科学研究院 | 2022-04-28 | — | — | WO | disclosed |
| EP-3936514-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2022-01-12 | — | — | EP | disclosed |
| US-20200323992-A1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2020-10-15 | — | — | US | disclosed |
| EP-3484892-B1 | 1,2,4-TRIAZOLO-[3,4-B]-1,3,4-THIADIAZOLE DERIVATIVES | GALENICA S A (GR) | 2020-08-26 | — | — | EP | disclosed |
| US-20190194228-A1 | NEW 1,2,4-TRIAZOLO-[3,4-b]-1,3,4-THIADIAZOLE DERIVATIVES | ENERGONBIO TECHNOLOGIES S.A. (GR) | 2019-06-27 | — | — | US | disclosed |
| US-10167287-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2019-01-01 | — | — | US | disclosed |
| WO-2018011414-A1 | NEW 1,2,4-TRIAZOLO-[3,4-b]-1,3,4-THIADIAZOLE DERIVATIVES | GALENICA S.A. (GR) | 2018-01-18 | — | — | WO | disclosed |
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2017-09-14 | — | — | US | disclosed |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | CHILDREN'S MEDICAL CENTER CORPORATION | 2012-10-04 | — | — | US | disclosed |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | CHILDREN'S MEDICAL CENTER CORPORATION | 2012-10-04 | — | — | US | disclosed |
| WO-2011035009-A1 | HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN | HERCULES TECHNOLOGY MANAGEMENT CO V, INC. (US) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10167287-B2 | Substituted pyrimidine compounds and methods of use and manufacture | DHFR, FOLR1, DPYD | DYRK1A 1384/4885TYMS 4/4885 |
| US-20170260190-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE | DHFR, FOLR1, DPYD | DYRK1A 1384/4885TYMS 4/4885 |
| US-20200323992-A1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | PAICS, MTHFD2, MTHFD1 | DYRK1A 1390/4885TYMS 14/4885 |
| US-20120252791-A1 | Heterocyclic GTP Cyclohydrolase 1 Inhibitors For the Treatment of Pain | GGH, GGPS1, GGT1 | DYRK1A 4681/4885TYMS 43/4885 |
| US-20190194228-A1 | NEW 1,2,4-TRIAZOLO-[3,4-b]-1,3,4-THIADIAZOLE DERIVATIVES | CYP4B1, CYP3A4, CYP1B1 | DYRK1A 2805/4885TYMS 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.