Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.55 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14459990 | 0.86 | LMNA (0.64) | LMNAALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL7130439 | 0.84 | LMNA (0.72) | LMNAALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL1976542 | 0.83 | POLB (0.65) | LMNAPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL21011063 | 0.83 | LMNA (0.54) | LMNAALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL14459989 | 0.82 | POLB (0.60) | LMNAPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13116745 | 0.81 | ALDH1A1 (0.68) | LMNAPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL15853630 | 0.80 | RORC (0.62) | POLB | |
| SCHEMBL14840498 | 0.80 | CYP46A1 (0.69) | POLBCYP2C19 | |
| Piberaline SCHEMBL49391 | 0.80 | L3MBTL1 (0.71) | LMNAALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL2701589 | 0.79 | CYP46A1 (0.53) | LMNAPOLBALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481649-B2 | Synthesis of a neurostimulative piperazine | NEURALSTEM, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-9481649-B2 | Synthesis of a neurostimulative piperazine | NEURALSTEM, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20160090358-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | NEURALSTEM, INC. (US) | 2016-03-31 | — | — | US | disclosed |
| US-20160090358-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | NEURALSTEM, INC. (US) | 2016-03-31 | — | — | US | disclosed |
| US-9278933-B2 | Synthesis of a neurostimulative piperazine | NEURALSTEM, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-9278933-B2 | Synthesis of a neurostimulative piperazine | NEURALSTEM, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| EP-2470182-B1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | NEURALSTEM INC (US) | 2014-06-04 | — | — | EP | disclosed |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130005974-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | NEURALSTEM, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-20130005974-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | NEURALSTEM, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-8338430-B2 | N-substituted piperazines | DOW AGROSCIENCES, LLC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338430-B2 | N-substituted piperazines | DOW AGROSCIENCES, LLC. (US) | 2012-12-25 | — | — | US | disclosed |
| WO-2011028548-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | NEURALSTEM, INC. (US) | 2011-03-10 | — | — | WO | disclosed |
| US-20100234391-A1 | N-SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100234391-A1 | N-SUBSTITUTED PIPERAZINES | DOW AGROSCIENCES LLC (US) | 2010-09-16 | — | — | US | disclosed |
| US-7754724-B2 | N-substituted piperazines | DOW AGROSCIENCES LLC (US) | 2010-07-13 | — | — | US | disclosed |
| US-7754724-B2 | N-substituted piperazines | DOW AGROSCIENCES LLC (US) | 2010-07-13 | — | — | US | disclosed |
| US-20070004750-A1 | N-substituted piperazines | CORTEVA AGRISCIENCE LLC | 2007-01-04 | — | — | US | disclosed |
| US-20070004750-A1 | N-substituted piperazines | CORTEVA AGRISCIENCE LLC | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004750-A1 | N-substituted piperazines | PRXL2A, CNPY2, CYP4X1 | LMNA 3135/4885POLB 4163/4885ALDH1A1 641/4885 |
| US-20100234391-A1 | N-SUBSTITUTED PIPERAZINES | PRXL2A, CNPY2, CYP4X1 | LMNA 3135/4885POLB 4163/4885ALDH1A1 641/4885 |
| US-20130005974-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | GAP43, AANAT, NNMT | LMNA 2898/4885POLB 2110/4885ALDH1A1 1359/4885 |
| US-20130072497-A1 | N- SUBSTITUTED PIPERAZINES | PRXL2A, CNPY2, CYP4X1 | LMNA 3135/4885POLB 4163/4885ALDH1A1 641/4885 |
| US-20160090358-A1 | SYNTHESIS OF A NEUROSTIMULATIVE PIPERAZINE | GAP43, AANAT, NNMT | LMNA 2898/4885POLB 2110/4885ALDH1A1 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.