Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16950980 | 0.83 | POLB (0.35) | POLBGAAGFERCA1CA2 | |
| SCHEMBL1081435 | 0.82 | CA12 (0.31) | CA1CA2CA7CA9CYP2D6 | |
| SCHEMBL6313678 | 0.81 | HTR2A (0.35) | CYP2D6TSHRACHEMEN1KMT2A | |
| SCHEMBL29010942 | 0.76 | — | — | |
| SCHEMBL8674 | 0.75 | CA2 (0.46) | POLBCA1CA2CA7CA9 | |
| SCHEMBL698305 | 0.75 | GABRA1 (0.33) | CA1CA2TSHRCYP1A2CYP3A4 | |
| SCHEMBL28463114 | 0.74 | ALDH1A1 (0.41) | GAAALDH1A1CYP1A2CYP3A4LMNA | |
| SCHEMBL21268198 | 0.74 | CYP1A2 (0.39) | ALDH1A1CYP1A2CYP3A4LMNATHRB | |
| SCHEMBL1817807 | 0.74 | KDM4E (0.40) | ALDH1A1CYP1A2CYP3A4LMNAHPGD | |
| SCHEMBL542567 | 0.73 | NPSR1 (0.35) | GAACA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194417-A1 | PHENOXY FLUOROPYRIMIDINES | BAYER AG (DE) | 2002-04-10 | — | — | EP | claimed |
| WO-2000078733-A1 | PHENOXY FLUOROPYRIMIDINES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-12-28 | — | — | WO | claimed |
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-05-03 | — | — | US | disclosed |
| US-20110269775-A1 | Piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-8017612-B2 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | JAPAN TOBACCO INC. (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20110218205-A1 | Piperazine derivatives | M'S SCIENCE CORP. | 2011-09-08 | — | — | US | disclosed |
| US-7985751-B2 | Piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2011-07-26 | — | — | US | disclosed |
| US-20090143395-A1 | Piperazine Derivatives | SUN CONNIE L | 2009-06-04 | — | — | US | disclosed |
| EP-2009004-A1 | NOVEL PIPERAZINE COMPOUND, AND USE THEREOF AS HCV POLYMERASE INHIBITOR | Japan Tobacco, Inc. (JP) | 2008-12-31 | — | — | EP | disclosed |
| EP-1931347-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-06-18 | — | — | EP | disclosed |
| US-20080081818-A1 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | JAPAN TOBACCO INC. (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-0726256-A1 | 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders | EGIS GYOGYSZERGYAR RT. (HU) | 1996-08-14 | — | — | EP | disclosed |
| EP-0012452-B1 | PHOSPHORIC ACID ESTERS AND THEIR USE IN PESTICIDAL COMPOSITIONS | BAYER AG (DE) | 1983-02-09 | — | — | EP | disclosed |
| EP-0000127-B1 | INSECTICIDAL AND ACARICIDAL COMPOSITIONS, THEIR MANUFACTURE AND THEIR USE | BAYER AG (DE) | 1982-10-20 | — | — | EP | disclosed |
| EP-0030661-A2 | Insecticidal and acaricidal agents containing propargyl esters of thiono-phosphoric acids | BAYER AG (DE) | 1981-06-24 | — | — | EP | disclosed |
| US-4257987-A | SYNERGISTIC ARTHROPODICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1981-03-24 | — | — | US | disclosed |
| EP-0025179-A1 | Process for the preparation of methane-phosphonic acid esters containing propargyl groups | BAYER AG (DE) | 1981-03-18 | — | — | EP | disclosed |
| EP-0012452-A2 | Phosphoric acid esters and their use in pesticidal compositions | BAYER AG (DE) | 1980-06-25 | — | — | EP | disclosed |
| US-4136100-A | BLUE-VIOLET TO GREEN-BLUE DYEINGS ON CELLULOSE TEXTILES | BASF AKTIENGESELLSCHAFT (DE) | 1979-01-23 | — | — | US | disclosed |
| EP-0000127-A1 | Insecticidal and acaricidal compositions, their manufacture and their use | BAYER AG (DE) | 1979-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081818-A1 | therapeutic agent for hepatitis C; R)-4-(4-trifluoromethyl-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 3-(4-isopropyl-benzylamide) 1-pyridin-4-ylamide; enzyme inhibitors | HAVCR2, AADAC, DNPEP | POLB 573/4885GAA 374/4885GFER 1239/4885 |
| US-20110269775-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRL1 | POLB 2061/4885GAA 3242/4885GFER 2895/4885 |
| US-20120107273-A1 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR | POLR1C, POLR2E, POLR2H | POLB 28/4885GAA 697/4885GFER 2588/4885 |
| US-20090143395-A1 | Piperazine Derivatives | SIGMAR1, OPRK1, OPRL1 | POLB 2061/4885GAA 3242/4885GFER 2895/4885 |
| US-20110218205-A1 | Piperazine derivatives | SIGMAR1, OPRK1, OPRM1 | POLB 1972/4885GAA 2447/4885GFER 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.