Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.55 |
| ▸ | FEN1 | P39748 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 4/20 | 0.50 |
| ▸ | FLT4 | P35916 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL1151256 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL29653755 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL6231168 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL11269243 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| Potassium Ion SCHEMBL6584264 | 0.83 | ALDH1A1 (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4446245 | 0.80 | CA1 (0.52) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL28510712 | 0.80 | ALDH1A1 (0.48) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL30185351 | 0.79 | SMN1; SMN2 (0.71) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL8065539 | 0.79 | SMN1; SMN2 (0.71) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL180845 | 0.79 | SMN1; SMN2 (0.71) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10272654-B2 | Polycarbonate composition having improved flame resistance for extrusion applications | COVESTRO DEUTSCHLAND AG (DE) | 2019-04-30 | — | — | US | claimed |
| EP-2785782-B1 | UV-STABILIZED, GLASS-FIBER REINFORCED, FLAME-RETARDANT POLYCARBONATES FOR THE EE AND IT SECTOR | COVESTRO DEUTSCHLAND AG (DE) | 2016-11-02 | — | — | EP | claimed |
| EP-2525972-B1 | FLAME-PROTECTED ARTICLE HAVING A HIGH LEVEL OF TRANSMISSION | COVESTRO DEUTSCHLAND AG (DE) | 2016-11-02 | — | — | EP | claimed |
| EP-2785783-B1 | ETHYLENE-PROPYLENE-MALEIC ACID ANHYDRIDE COPOLYMER AS IMPACT MODIFIER IN GLASS-FIBER REINFORCED, FLAME-RETARDANT POLYCARBONATES FOR THE EE SECTOR | COVESTRO DEUTSCHLAND AG (DE) | 2016-09-28 | — | — | EP | claimed |
| US-20150232644-A1 | PRODUCTS WITH IMPROVED NON-FLAMMABILITY | COVESTRO DEUTSCHLAND AG (DE) | 2015-08-20 | — | — | US | claimed |
| EP-1214378-B1 | FLAME RETARDANT POLYCARBONATE COMPOSITION | BAYER AG (US) | 2005-04-06 | — | — | EP | claimed |
| EP-1214378-A1 | FLAME RETARDANT POLYCARBONATE COMPOSITION | Bayer Corporation (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001010957-A1 | FLAME RETARDANT POLYCARBONATE COMPOSITION | BAYER CORPORATION (US) | 2001-02-15 | — | — | WO | claimed |
| US-6180702-B1 | A BLENDS COMPRISING POLYALKYL METHACRYLATE WITH FLUORINATED POLYOLEFIN, AND THE SALT SELECT FROM AN ALKALI METAL OR ALKALINE EARTH METAL SALT OF PERFLUOROALKANE SULFONIC ACID, AROMATIC SULFIMIDE, OR AROMATIC SULFONIC ACID | BAYER CORPORATION | 2001-01-30 | — | — | US | claimed |
| CN-114805051-B | Method for preparing 2, 4-dichlorobenzoic acid from propiconazole 4-H isomer | 浙江宇龙生物科技股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| US-11472099-B2 | Method for producing an object by means of an additive manufacturing process using a polycarbonate building material with improved flowability | COVESTRO DEUTSCHLAND AG (DE) | 2022-10-18 | — | — | US | disclosed |
| CN-110267798-B | Method of manufacturing an object by additive manufacturing using a polycarbonate build material having improved flow capability | 科思创德国股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-107207864-B | Flame-resistant moulding compositions containing glass fibres, containing silicone-containing polycarbonate block cocondensates | 科思创德国股份有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-107207863-B | Flame-resistant moulding compositions containing silicone-containing polycarbonate block cocondensates | 科思创德国股份有限公司 | 2021-02-19 | — | — | CN | disclosed |
| US-4649168-A | Process for the preparation of flame-resistant polycarbonate moulding compositions containing tetrafluoroethylene polymers | BAYER AKTIENGESELLSCHAFT (DE) | 1987-03-10 | — | — | US | disclosed |
| EP-0182226-A2 | Process for the preparation of flame-retardant tetrafluoroethylene-polymerisate containing polycarbonate moulding compositions | BAYER AG (DE) | 1986-05-28 | — | — | EP | disclosed |
| EP-0024331-B1 | PROCESS FOR PREPARING FLAME-RESISTANT POLYCARBONATES | BAYER AG (DE) | 1983-05-25 | — | — | EP | disclosed |
| US-4289685-A | WASHING UNTIL NEUTRAL AND FREE OF ELECTROLYTES, DISPERSING FIREPROOFING SALT, EVAPORATION OF WATER AND SOLVENT | BAYER AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0024331-A1 | Process for preparing flame-resistant polycarbonates | BAYER AG (DE) | 1981-03-04 | — | — | EP | disclosed |
| US-4208489-A | AN ALKALI METAL SALT AND A TETRAHALOGENOPHTHALIMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1980-06-17 | — | — | US | disclosed |