Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.50 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.55 |
| ▸ | FEN1 | P39748 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231168 | 1.00 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| Silver SCHEMBL1151256 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL11269243 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| Potassium Ion SCHEMBL1303475 | 0.96 | TSHR (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4446245 | 0.84 | CA1 (0.52) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL8822154 | 0.83 | CA1 (0.50) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL28343765 | 0.83 | ALDH1A1 (0.63) | TSHRCASP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL31384757 | 0.81 | CA2 (0.54) | TSHRCASP1SMN1; SMN2KDM4ECA1 | |
| SCHEMBL28510712 | 0.80 | ALDH1A1 (0.48) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL30185351 | 0.79 | SMN1; SMN2 (0.71) | TSHRCASP1SMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433069-A | Preparation method of 2, 4-dichlorobenzaldehyde | 柳州东风容泰化工股份有限公司 | 2022-12-06 | — | — | CN | claimed |
| CN-115433069-A | Preparation method of 2, 4-dichlorobenzaldehyde | 柳州东风容泰化工股份有限公司 | 2022-12-06 | — | — | CN | disclosed |
| US-11472099-B2 | Method for producing an object by means of an additive manufacturing process using a polycarbonate building material with improved flowability | COVESTRO DEUTSCHLAND AG (DE) | 2022-10-18 | — | — | US | disclosed |
| CN-110267798-B | Method of manufacturing an object by additive manufacturing using a polycarbonate build material having improved flow capability | 科思创德国股份有限公司 | 2022-05-27 | — | — | CN | disclosed |