Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035484 | 0.76 | OPRM1 (0.36) | MEN1KMT2A | |
| SCHEMBL696010 | 0.74 | — | — | |
| SCHEMBL22885170 | 0.74 | MEN1 (0.34) | MEN1CYP2C9KMT2ATRIM24TRIM33 | |
| Hydrochloric Acid SCHEMBL1201605 | 0.72 | ALDH1A1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL345144 | 0.72 | — | — | |
| SCHEMBL2106510 | 0.70 | CYP11B2 (0.36) | MEN1CYP2C9KMT2ATRIM24TRIM33 | |
| Hydrochloric Acid SCHEMBL1273427 | 0.69 | — | — | |
| SCHEMBL75984 | 0.69 | — | — | |
| SCHEMBL1139426 | 0.69 | — | — | |
| SCHEMBL18635870 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487778-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANOLS | GRUENENTHAL GMBH (DE) | 2012-07-11 | — | — | EP | claimed |
| US-7678834-B2 | Substituted 4-aminocyclohexanol compounds | GRUENENTHAL GMBH (DE) | 2010-03-16 | — | — | US | claimed |
| EP-1406858-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANOLS | GRUENENTHAL GMBH (DE) | 2009-07-01 | — | — | EP | claimed |
| EP-1406859-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANOL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2008-01-02 | — | — | EP | claimed |
| US-7276518-B2 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-10-02 | — | — | US | claimed |
| EP-1385825-B1 | SUBSTITUTED 2-PYRIDINE-CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-08-15 | — | — | EP | claimed |
| US-7211694-B2 | Substituted 4-aminocyclohexanols | GRUENENTHAL GMBH (DE) | 2007-05-01 | — | — | US | claimed |
| EP-1392641-B1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-04-11 | — | — | EP | claimed |
| US-7183436-B2 | Substituted 4-aminocyclohexanols | GRUENENTHAL GMBH (DE) | 2007-02-27 | — | — | US | claimed |
| US-20050187220-A1 | Substituted 4-aminocyclohexanols | GRUENENTHAL GMBH (DE) | 2005-08-25 | — | — | US | claimed |
| US-20040236104-A1 | Substituted 4-aminocyclohexanols | GRUENENTHAL GMBH (DE) | 2004-11-25 | — | — | US | claimed |
| US-20040214822-A1 | Substituted 4-aminocyclohexanol compounds | GRUENENTHAL GMBH (DE) | 2004-10-28 | — | — | US | claimed |
| CN-1533374-A | Substitutled cyclohexane-1,4-diamine derivatives | — | 2004-09-29 | — | — | CN | claimed |
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2004-08-19 | — | — | US | claimed |
| US-9862719-B2 | Process or preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds | GRUENENTHAL GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-20150322080-A1 | Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds | ADNEURIS THERAPEUTICS, INC. | 2015-11-12 | — | — | US | disclosed |
| US-9120797-B2 | Process for preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds | GRUENENTHAL GMBH (DE) | 2015-09-01 | — | — | US | disclosed |
| US-4212878-A | Phenylacetamide derivative analgesics | THE UPJOHN COMPANY (US) | 1980-07-15 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214822-A1 | Substituted 4-aminocyclohexanol compounds | ADRA2C, OPRD1, OPRK1 | MEN1 2907/4885CYP2C9 56/4885KMT2A 3124/4885 |
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | DPYD, DDC, QDPR | MEN1 1475/4885CYP2C9 110/4885KMT2A 2496/4885 |
| US-20050187220-A1 | Substituted 4-aminocyclohexanols | ADRA2C, OPRK1, OPRD1 | MEN1 3383/4885CYP2C9 43/4885KMT2A 2824/4885 |
| US-20150322080-A1 | Process for Preparing Spirocyclic Cyclohexane Compounds, Compositions Containing Such Compounds and Method of Using Such Compounds | PKD1, VKORC1, PKD2 | MEN1 740/4885CYP2C9 63/4885KMT2A 4429/4885 |
| US-20040236104-A1 | Substituted 4-aminocyclohexanols | CNR2, OPRK1, OPRL1 | MEN1 3028/4885CYP2C9 386/4885KMT2A 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.