Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19830553 | 0.85 | NPC1 (0.44) | ALOX5RAB9ANPC1KMT2ACES2 | |
| SCHEMBL15765746 | 0.81 | ALOX5 (0.42) | ALOX5RAB9ANPC1KMT2ACES2 | |
| SCHEMBL4622045 | 0.81 | NPC1 (0.39) | ALOX5RAB9ANPC1KMT2ACES2 | |
| SCHEMBL27612380 | 0.79 | LMNA (0.39) | ALOX5RAB9ANPC1KMT2ASLC5A2 | |
| SCHEMBL1535344 | 0.79 | RAB9A (0.40) | ALOX5RAB9ANPC1KMT2ACES2 | |
| Methylamine SCHEMBL28554106 | 0.77 | NPC1 (0.44) | ALOX5RAB9ANPC1KMT2ACES2 | |
| SCHEMBL6236376 | 0.76 | NPC1 (0.41) | ALOX5RAB9ANPC1KMT2ACES2 | |
| SCHEMBL7296321 | 0.76 | — | — | |
| SCHEMBL2849489 | 0.76 | — | — | |
| SCHEMBL1232757 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8269023-B2 | Process for preparation of duloxetine hydrochloride | LUPIN LTD. (IN) | 2012-09-18 | — | — | US | claimed |
| US-20110275835-A1 | PROCESS FOR PREPARING (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE BY USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS INTERMEDIATE | SCI PHARMTECH, INC. (TW) | 2011-11-10 | — | — | US | claimed |
| US-20100105925-A1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LIMITED (IN) | 2010-04-29 | — | — | US | claimed |
| EP-2132192-A2 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | Lupin Limited (IN) | 2009-12-16 | — | — | EP | claimed |
| WO-2008107911-A2 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LIMITED (IN) | 2008-09-12 | — | — | WO | claimed |
| EP-2132192-B1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LTD (IN) | 2013-04-24 | — | — | EP | disclosed |
| US-8269023-B2 | Process for preparation of duloxetine hydrochloride | LUPIN LTD. (IN) | 2012-09-18 | — | — | US | disclosed |
| US-20100105925-A1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LIMITED (IN) | 2010-04-29 | — | — | US | disclosed |
| WO-2010025287-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE | CODEXIS, INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| EP-2132192-A2 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | Lupin Limited (IN) | 2009-12-16 | — | — | EP | disclosed |
| CN-101337958-A | Process for preparing 3-methylamino-1- (2-thienyl) -1-propanol compounds | ZHEJIANG LIAOYUAN PHARMACEUTIC (CN) | 2009-01-07 | — | — | CN | disclosed |
| US-7435563-B2 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-14 | — | — | US | disclosed |
| US-7435563-B2 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-14 | — | — | US | disclosed |
| WO-2008107911-A2 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LIMITED (IN) | 2008-09-12 | — | — | WO | disclosed |
| EP-1789385-A1 | METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-30 | — | — | EP | disclosed |
| US-20050245749-A1 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol | BASF AKTIENGESELLSCHAFT (DE) | 2005-11-03 | — | — | US | disclosed |
| US-20050245749-A1 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol | BASF AKTIENGESELLSCHAFT (DE) | 2005-11-03 | — | — | US | disclosed |
| WO-2005085192-A1 | METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245749-A1 | Method for the production of (s)-3-methylamino-1-(thien-2-yl)propan-1-ol | INMT, PNMT, TH | ALOX5 1531/4885RAB9A 4672/4885NPC1 3649/4885 |
| US-20110275835-A1 | PROCESS FOR PREPARING (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE BY USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS INTERMEDIATE | PNMT, HNMT, INMT | ALOX5 546/4885RAB9A 4113/4885NPC1 859/4885 |
| US-20100105925-A1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | MAOA, SLC6A3, PNMT | ALOX5 3276/4885RAB9A 1260/4885NPC1 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.