Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29954713 | 0.86 | HTR7 (0.36) | HTR7MAPTCYP1A2CYP2C19LRRK2 | |
| SCHEMBL29952427 | 0.79 | EPHX2 (0.40) | MAPTCYP1A2CYP2C19CA12CA1 | |
| SCHEMBL29953205 | 0.79 | PGR (0.43) | HTR2CMAPTCYP1A2CYP2C19KMT2A | |
| SCHEMBL29954649 | 0.79 | TP53 (0.46) | MAPTCA12CA1CA2CA4 | |
| SCHEMBL29951858 | 0.76 | MAOA (0.48) | MAPTCA12CA1CA2CA4 | |
| SCHEMBL29955187 | 0.76 | PIM1 (0.39) | MAPTKMT2APIM1 | |
| SCHEMBL29956445 | 0.76 | SMN1; SMN2 (0.40) | MAPTKMT2APIM1PIM2 | |
| SCHEMBL24112727 | 0.75 | PGR (0.53) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL2263637 | 0.75 | PGR (0.53) | HTR7DRD2DRD1HTR2AHTR2C | |
| SCHEMBL23869671 | 0.75 | HTR7 (0.39) | HTR7DRD2DRD1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | disclosed |
| US-8846953-B2 | Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles | SCINOPHARM TAIWAN, LTD. (TW) | 2014-09-30 | — | — | US | disclosed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | disclosed |
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM TAIWAN, LTD. (TW) | 2013-07-25 | — | — | US | disclosed |
| WO-2012058780-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD. (CN) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012059941-A1 | PROCESS FOR PREPARATION OF SUNITINIB MALATE AND SALTS THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |
| US-20110275689-A1 | Preparation of 3-Pyrrole Substituted 2-Indolinone Derivatives | GENERICS [UK] LIMITED (GB) | 2011-11-10 | — | — | US | disclosed |
| US-20110275689-A1 | Preparation of 3-Pyrrole Substituted 2-Indolinone Derivatives | GENERICS [UK] LIMITED (GB) | 2011-11-10 | — | — | US | disclosed |
| US-20110275689-A1 | Preparation of 3-Pyrrole Substituted 2-Indolinone Derivatives | GENERICS [UK] LIMITED (GB) | 2011-11-10 | — | — | US | disclosed |
| WO-2011128699-A2 | NOVEL PROCESS | GENERICS [UK] LIMITED (GB) | 2011-10-20 | — | — | WO | disclosed |
| CN-102137842-A | Preparation of 3-pyrrole substituted 2-indolinone derivatives | GENERICS UK LTD | 2011-07-27 | — | — | CN | disclosed |
| EP-2318364-A2 | PREPARATION OF 3-PYRROLE SUBSTITUTED 2-INDOLINONE DERIVATIVES | Generics [UK] Limited (GB) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010001167-A2 | NOVEL PROCESS | GENERICS [UK] LIMITED (GB) | 2010-01-07 | — | — | WO | disclosed |
| WO-2010001167-A2 | NOVEL PROCESS | GENERICS [UK] LIMITED (GB) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190512-A1 | PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES | SKP2, SDHA, MDH2 | HTR7 3018/4885DRD2 3653/4885DRD1 4090/4885 |
| US-20110275689-A1 | Preparation of 3-Pyrrole Substituted 2-Indolinone Derivatives | CDC25C, PYCR1, ALDH18A1 | HTR7 1799/4885DRD2 1060/4885DRD1 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.