Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 4/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 6/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849192 | 0.92 | PRKCQ (0.42) | MERTKTYRO3AXLJAK3CTNNB1 | |
| SCHEMBL13173260 | 0.88 | ACHE (0.48) | SIRT5CTNNB1TCF7L2ACHEBACE1 | |
| SCHEMBL2838318 | 0.82 | PYGL (0.34) | MERTKTYRO3FLT3GAS6AXL | |
| SCHEMBL2845731 | 0.82 | NUDT1 (0.39) | MERTKTYRO3FLT3GAS6AXL | |
| SCHEMBL2847267 | 0.80 | MCHR1 (0.51) | CTNNB1TCF7L2ACHEBACE1KCNH2 | |
| SCHEMBL2845283 | 0.73 | KCNH2 (0.49) | KCNH2 | |
| SCHEMBL2843829 | 0.72 | KCNH2 (0.48) | KCNH2 | |
| Maleic Acid SCHEMBL2850208 | 0.69 | SIGMAR1 (0.52) | KCNH2 | |
| Fumaric Acid SCHEMBL2850216 | 0.69 | SIGMAR1 (0.52) | KCNH2 | |
| SCHEMBL4199649 | 0.67 | CCR5 (0.34) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156817-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-13 | — | — | US | disclosed |
| US-9139559-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-09-22 | — | — | US | disclosed |
| US-20140336209-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2014-11-13 | — | — | US | disclosed |
| US-20140221409-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| US-20120258978-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258978-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, BDNF | MERTK 1819/4885TYRO3 430/4885FLT3 245/4885 |
| US-20140221409-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, NRP1 | MERTK 1517/4885TYRO3 488/4885FLT3 225/4885 |
| US-20140336209-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, NRP1 | MERTK 1517/4885TYRO3 488/4885FLT3 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.