Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13173250 | 0.92 | MERTK (0.38) | TYRO3AXLMERTKJAK3CTNNB1 | |
| SCHEMBL2847267 | 0.89 | MCHR1 (0.51) | CCR5VNN1MCHR1CTNNB1TCF7L2 | |
| SCHEMBL13173260 | 0.80 | ACHE (0.48) | MCHR1CTNNB1TCF7L2 | |
| SCHEMBL2845731 | 0.80 | NUDT1 (0.39) | TYRO3AXLMERTK | |
| SCHEMBL2838318 | 0.80 | PYGL (0.34) | CCR5TYRO3AXLMERTK | |
| SCHEMBL2845283 | 0.70 | KCNH2 (0.49) | CCR5 | |
| SCHEMBL2843829 | 0.70 | KCNH2 (0.48) | CCR5 | |
| Maleic Acid SCHEMBL2850208 | 0.67 | SIGMAR1 (0.52) | TDP1 | |
| Fumaric Acid SCHEMBL2850216 | 0.67 | SIGMAR1 (0.52) | TDP1 | |
| SCHEMBL4199649 | 0.65 | CCR5 (0.34) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2679586-B1 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO CO LTD (JP) | 2016-02-10 | — | — | EP | disclosed |
| US-9156817-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-13 | — | — | US | disclosed |
| US-9156817-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-13 | — | — | US | disclosed |
| US-9139559-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-09-22 | — | — | US | disclosed |
| US-9139559-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-09-22 | — | — | US | disclosed |
| US-20140336209-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2014-11-13 | — | — | US | disclosed |
| US-20140336209-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO CO LTD (JP) | 2014-11-13 | — | — | US | disclosed |
| US-20140221409-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| US-20140221409-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-07 | — | — | US | disclosed |
| EP-2679586-A1 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | Daiichi Sankyo Company, Limited (JP) | 2014-01-01 | — | — | EP | disclosed |
| US-8592435-B2 | Nitrogen-containing six-membered aromatic ring derivatives and pharmaceutical products containing the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-11-26 | — | — | US | disclosed |
| US-20120258978-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-10-11 | — | — | US | disclosed |
| US-20100130739-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | ASUBIO PHARMA CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130739-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | ASUBIO PHARMA CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| US-20100130739-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | ASUBIO PHARMA CO., LTD. (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-2151439-A1 | NITROGENATED AROMATIC 6-MEMBERED RING DERIVATIVE, AND PHARMACEUTICAL AGENT COMPRISING THE SAME | Asubio Pharma Co., Ltd. (JP) | 2010-02-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258978-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, BDNF | PRKCQ 3831/4885CCR5 387/4885TYRO3 430/4885 |
| US-20140221409-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, NRP1 | PRKCQ 3751/4885CCR5 381/4885TYRO3 488/4885 |
| US-20140336209-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, NRP1 | PRKCQ 3751/4885CCR5 381/4885TYRO3 488/4885 |
| US-20100130739-A1 | NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME | NGF, VEGFA, NRP1 | PRKCQ 3751/4885CCR5 381/4885TYRO3 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.