SCHEMBL13360485

SCHEMBL13360485

Cc1sc2ccccc2c1C(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.46
ALDH1A1 P00352 2/20 0.41
CYP2D6 P10635 8/20 0.37
CYP1A2 P05177 2/20 0.37
CYP3A4 P08684 2/20 0.37
CYP1A1 P04798 1/20 0.37
CYP2C9 P11712 1/20 0.37
HTR2A P28223 1/20 0.37
CYP2C19 P33261 1/20 0.37
TSHR P16473 1/20 0.37
NFKB1 P19838 1/20 0.37
HSD17B10 Q99714 1/20 0.37
FTO Q9C0B1 1/20 0.37
HRH1 P35367 8/20 0.36
CHRM1 P11229 5/20 0.36
KCNH2 Q12809 4/20 0.36
MAPT P10636 3/20 0.36
HPGD P15428 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12896179 0.79 GPR3 (0.46) GPR3ALDH1A1CYP2D6CYP3A4HRH1
SCHEMBL1098011 0.78 IDO1 (0.44) GPR3ALDH1A1CYP2D6CYP3A4HSD17B10
SCHEMBL9967691 0.78 MAPT (0.51) GPR3ALDH1A1CYP2D6CYP3A4TSHR
SCHEMBL14156519 0.75 CNR2 (0.43) GPR3CYP2D6CYP3A4HRH1CHRM1
SCHEMBL13999482 0.75 GPR3 (0.41) GPR3ALDH1A1CYP2D6CYP3A4HRH1
SCHEMBL716184 0.73 KDM4E (0.40) GPR3ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL714982 0.73 HRH1 (0.42) GPR3CYP2D6CYP3A4HRH1CHRM1
SCHEMBL19135538 0.73 ACHE (0.38) CYP2D6CYP3A4HRH1CHRM1KCNH2
SCHEMBL12922994 0.73 BCKDK (0.38) ALDH1A1MAPTSMN1; SMN2MEN1LMNA
SCHEMBL144440 0.73 GPR3 (0.55) GPR3ALDH1A1CYP2D6CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230167139-A1 PHOTOCHROMIC GERMOLE-FUSED DIARYLETHENES AND PRODUCTION THEREOF THE UNIVERSITY OF HONG KONG (CN) 2023-06-01 US disclosed
US-20230167139-A1 PHOTOCHROMIC GERMOLE-FUSED DIARYLETHENES AND PRODUCTION THEREOF THE UNIVERSITY OF HONG KONG (CN) 2023-06-01 US disclosed
US-20210147406-A1 5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK BRISTOL MYERS SQUIBB CO (US) 2021-05-20 US disclosed
WO-2020249664-A1 SULFONYLUREA DERIVATIVES AND USES THEREOF NodThera Limited (GB) 2020-12-17 WO disclosed
US-20200131144-A1 AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS PHENEX-FXR GMBH (DE) 2020-04-30 US disclosed
US-20200115357-A1 LIVER X RECEPTORS (LXR) MODULATORS PHENEX-FXR GMBH (DE) 2020-04-16 US disclosed
US-20180051052-A1 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF SAGE THERAPEUTICS INC (US) 2018-02-22 US disclosed
US-20170290827-A1 INHIBITORS OF HEPATITIS C VIRUS GILEAD PHARMASSET LLC 2017-10-12 US disclosed
US-9365611-B2 19-NOR neuroactive steroids and methods of use thereof SAGE THERAPEUTICS, INC. (US) 2016-06-14 US disclosed
US-20160083418-A1 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF SAGE THERAPEUTICS, INC. 2016-03-24 US disclosed
US-7718648-B2 Pyridobenzazepine compounds and methods for inhibiting mitotic progression MILLENNIUM PHARMACEUTICALS, INC. (US) 2010-05-18 US disclosed
US-7572784-B2 Compounds and methods for inhibiting mitotic progression MILLENNIUM PHARMACEUTICALS, INC. (US) 2009-08-11 US disclosed
US-20080045501-A1 Pyridobenzazepine compounds and methods for inhibiting mitotic progression MILLENNIUM PHARMACEUTICALS, INC. (US) 2008-02-21 US disclosed
US-20070185087-A1 Compounds and methods for inhibiting mitotic progression MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180051052-A1 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF NR3C2, HSD3B1, NR3C1 GPR3 377/4885ALDH1A1 257/4885CYP2D6 671/4885
US-20210147406-A1 5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK MYLK, ROCK1, ROCK2 GPR3 1444/4885ALDH1A1 3032/4885CYP2D6 3726/4885
US-20070185087-A1 Compounds and methods for inhibiting mitotic progression AURKC, AURKA, AURKB GPR3 3607/4885ALDH1A1 3815/4885CYP2D6 4519/4885
US-20170290827-A1 INHIBITORS OF HEPATITIS C VIRUS HAVCR2, SLC10A1, GOT1 GPR3 4121/4885ALDH1A1 112/4885CYP2D6 77/4885
US-20080045501-A1 Pyridobenzazepine compounds and methods for inhibiting mitotic progression AURKB, AURKC, AURKA GPR3 2423/4885ALDH1A1 3480/4885CYP2D6 3288/4885
US-20160083418-A1 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF NR3C2, HSD3B1, HSD3B2 GPR3 354/4885ALDH1A1 313/4885CYP2D6 682/4885
US-20230167139-A1 PHOTOCHROMIC GERMOLE-FUSED DIARYLETHENES AND PRODUCTION THEREOF AGL, GMNN, GAK GPR3 640/4885ALDH1A1 1543/4885CYP2D6 529/4885
US-20200131144-A1 AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS NR1H2, NR1H3, NR1H4 GPR3 110/4885ALDH1A1 2016/4885CYP2D6 1206/4885
US-20200115357-A1 LIVER X RECEPTORS (LXR) MODULATORS NR1H2, NR1H3, NR1H4 GPR3 82/4885ALDH1A1 2980/4885CYP2D6 1542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.