Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292686 | 0.85 | HTR2A (0.57) | PTGS1AKR1C3CYP1A2LMNAPTGS2 | |
| SCHEMBL9546445 | 0.85 | PTGS1 (0.56) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| SCHEMBL29818641 | 0.85 | SLC6A4 (0.70) | TAAR1SLC6A4 | |
| SCHEMBL30824303 | 0.85 | PTGS1 (0.56) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| SCHEMBL9546449 | 0.85 | PTGS1 (0.56) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| SCHEMBL13484409 | 0.85 | SLC6A4 (0.70) | TAAR1SLC6A4 | |
| SCHEMBL30776613 | 0.85 | PTGS1 (0.56) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| Hydrochloric Acid SCHEMBL11281141 | 0.84 | SLC6A4 (0.68) | TAAR1SLC6A4 | |
| SCHEMBL21055097 | 0.83 | ALOX15 (0.50) | CYP1A2 | |
| SCHEMBL11015452 | 0.82 | PTGS1 (0.53) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130190497-A1 | FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2013-07-25 | — | — | US | disclosed |
| US-8337941-B2 | Fluorescent substrates for monoamine transporters as optical false neurotransmitters | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100035279-A1 | Fluorescent Substrates for Monoamine Transporters as Optical False Neurotransmitters | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
| US-7579479-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-20090170934-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NICOX SA | 2009-07-02 | — | — | US | disclosed |
| US-20090096314-A1 | ELECTRIC MOTOR | HONDA MOTOR CO., LTD. (JP) | 2009-04-16 | — | — | US | disclosed |
| US-7241780-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOLS-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | CHENG PETER T | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035279-A1 | Fluorescent Substrates for Monoamine Transporters as Optical False Neurotransmitters | SLC18A2, SLC6A2, SLC18A3 | PTGS1 2653/4885AKR1C3 1010/4885AKR1C2 1341/4885 |
| US-20130190497-A1 | FLUORESCENT SUBSTRATES FOR MONOAMINE TRANSPORTERS AS OPTICAL FALSE NEUROTRANSMITTERS | SLC18A2, SLC6A2, SLC18A3 | PTGS1 2653/4885AKR1C3 1010/4885AKR1C2 1341/4885 |
| US-20090170934-A1 | MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC | NOS2, NOS1, NOS3 | PTGS1 28/4885AKR1C3 39/4885AKR1C2 65/4885 |
| US-20070015797-A1 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | GPR119, LIPC, ACACA | PTGS1 3434/4885AKR1C3 524/4885AKR1C2 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.