Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | BACE1 | P56817 | 4/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GGT1 | P19440 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HNF4A | P41235 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719162 | 0.90 | KDM4E (0.71) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL16248157 | 0.86 | KDM4E (0.59) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL16599434 | 0.86 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL18143536 | 0.86 | HNF4A (0.58) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL16599456 | 0.84 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL27870015 | 0.84 | ALDH1A1 (0.52) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL16599443 | 0.84 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL8667165 | 0.84 | KDM4E (0.79) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL28553726 | 0.83 | BACE1 (0.50) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL4632581 | 0.83 | HNF4A (0.58) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196469-A1 | Conjugates with anti-inflammatory activity | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2010-06-16 | — | — | EP | claimed |
| EP-1633771-B1 | MACROLIDE-CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY | GLAXOSMITHKLINE ZAGREB (HR) | 2009-07-15 | — | — | EP | claimed |
| EP-2070940-A1 | Compounds with anti-inflammatory activity | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2009-06-17 | — | — | EP | claimed |
| EP-1551865-B1 | HYBRID MOLECULES OF MACROLIDES WITH STEROIDAL/NON-STEROIDAL ANTI-INFLAMMATORY MOLECULES | GLAXOSMITHKLINE ZAGREB (HR) | 2009-04-22 | — | — | EP | claimed |
| US-20090048221-A1 | Conjugates with Anti-Inflammatory Activity | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2009-02-19 | — | — | US | claimed |
| CN-100393741-C | Macrolide complexes with anti-inflammatory activity | PLIVA ISTRAZIVACKI INST DOO (HR) | 2008-06-11 | — | — | CN | claimed |
| CN-101090908-A | Conjugates with anti-inflammatory activity | PLIVA ISTRAZIVACKI INST D O O (HR) | 2007-12-19 | — | — | CN | claimed |
| EP-1805202-A2 | CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2007-07-11 | — | — | EP | claimed |
| EP-1778292-A2 | USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-05-02 | — | — | EP | claimed |
| US-7157433-B2 | Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB (HR) | 2007-01-02 | — | — | US | claimed |
| WO-2006018698-A2 | USE OF CELL-SPECIFIC CONJUGATES FOR TREATMENT OF INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (US) | 2006-02-23 | — | — | WO | claimed |
| US-20060035845-A1 | Use of immune cell specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. | 2006-02-16 | — | — | US | claimed |
| EP-1551865-A2 | HYBRID MOLCULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-07-13 | — | — | EP | claimed |
| US-20050080003-A1 | Compounds with anti-inflammatory activity | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2005-04-14 | — | — | US | claimed |
| EP-1521763-A2 | NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE | Pliva - Istrazivacki Institut d.o.o. (HR) | 2005-04-13 | — | — | EP | claimed |
| WO-2004094449-A1 | MACROLIDE-CONJUGATES WITH ANTI-INFLAMMATORY ACTIVITY | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (US) | 2004-11-04 | — | — | WO | claimed |
| US-20040097434-A1 | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use | PLIVA PHARMACEUTICAL INDUSTRY, INCORPORATED | 2004-05-20 | — | — | US | claimed |
| US-20040077612-A1 | Novel compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules | PLIVA DD (HR) | 2004-04-22 | — | — | US | claimed |
| WO-2004005313-A2 | HYBRID MOLECULES OF MACROLIDES WITH STEROID/NON-STEROID ANTI-INFLAMMATORY, ANTINEOPLASTIC AND ANTIVIRAL ACTIVE MOLECULES | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (US) | 2004-01-15 | — | — | WO | claimed |
| WO-2004005309-A2 | NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE | PLIVA - ISTRAZIVACKI INSTITUT D.O.O. (US) | 2004-01-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080003-A1 | Compounds with anti-inflammatory activity | NOD1, NOD2, TNF | KDM4E 3272/4885HSD17B10 367/4885ALDH1A1 3203/4885 |
| US-20060035845-A1 | Use of immune cell specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract | SI, MALT1, CD4 | KDM4E 1989/4885HSD17B10 263/4885ALDH1A1 1354/4885 |
| US-20090048221-A1 | Conjugates with Anti-Inflammatory Activity | MPO, EPX, NOD1 | KDM4E 2438/4885HSD17B10 595/4885ALDH1A1 2901/4885 |
| US-20040097434-A1 | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use | PTGS1, IL1B, LTB4R2 | KDM4E 3705/4885HSD17B10 476/4885ALDH1A1 505/4885 |
| US-20040077612-A1 | Novel compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules | MALT1, TNF, IL1B | KDM4E 2444/4885HSD17B10 532/4885ALDH1A1 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.