Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13336146 | 0.87 | LMNA (0.46) | NR1H4SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL20322973 | 0.84 | SLC6A9 (0.46) | KEAP1NFE2L2SRD5A2CYP1A2SLC6A9 | |
| SCHEMBL14463145 | 0.83 | NR1H4 (0.49) | NR1H4SMN1; SMN2KEAP1NFE2L2RAB9A | |
| SCHEMBL9078636 | 0.80 | NR1H4 (0.47) | NR1H4SMN1; SMN2KEAP1NFE2L2RAB9A | |
| SCHEMBL6493549 | 0.80 | MLYCD (0.63) | SMN1; SMN2NPSR1LMNAMLYCD | |
| SCHEMBL13757716 | 0.79 | MLYCD (0.48) | NR1H4SMN1; SMN2KEAP1NFE2L2MEN1 | |
| SCHEMBL797850 | 0.79 | CA2 (0.43) | KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL3348892 | 0.79 | KEAP1 (0.54) | SMN1; SMN2KEAP1NFE2L2RAB9AKMT2A | |
| SCHEMBL13624059 | 0.78 | HCRTR2 (0.46) | NR1H4SMN1; SMN2RAB9AMEN1KMT2A | |
| SCHEMBL196635 | 0.78 | KMT2A (0.49) | SMN1; SMN2RAB9AMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | TEIJIN PHARMA LIMITED (JP) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291945-A1 | CYSTEINE PROTEASE INHIBITORS | CTSE, SPINT2, CTSF | NR1H4 2500/4885SMN1; SMN2 4525/4885KEAP1 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.