Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628861 | 0.85 | RAB9A (0.38) | RAB9ANPC1NOTUMTSHRMAPK1 | |
| SCHEMBL13628851 | 0.82 | PTGS2 (0.36) | PTGS2TSHRTBXA2RALDH1A1HTT | |
| SCHEMBL13628832 | 0.80 | TRPC5 (0.38) | RAB9ANPC1PTGS2TSHRMAPK1 | |
| SCHEMBL13628859 | 0.80 | PTGS2 (0.45) | PTGS2TBXA2RPOLB | |
| SCHEMBL13628853 | 0.79 | PTGS2 (0.37) | PTGS2TSHRTBXA2RALDH1A1MAPT | |
| SCHEMBL2925335 | 0.78 | PTGS2 (0.56) | RAB9ANPC1PTGS2NOTUMTSHR | |
| SCHEMBL13628850 | 0.77 | PTGS2 (0.36) | RAB9APTGS2TSHRTBXA2RMAPT | |
| SCHEMBL13628847 | 0.77 | CYP11B2 (0.43) | PTGS2MAPT | |
| SCHEMBL13628821 | 0.77 | MAPT (0.37) | RAB9APTGS2TSHRMAPK1TBXA2R | |
| SCHEMBL13628857 | 0.77 | CCR2 (0.40) | PTGS2TSHRTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |