Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628847 | 0.88 | CYP11B2 (0.43) | PTGS2GNRHRACLY | |
| SCHEMBL13628860 | 0.85 | PTGS2 (0.46) | PTGS2TP53GNRHRTBXA2R | |
| SCHEMBL13628821 | 0.82 | MAPT (0.37) | PTGS2TP53TBXA2R | |
| SCHEMBL13628848 | 0.81 | PTGS2 (0.42) | PTGS2GNRHR | |
| SCHEMBL13628853 | 0.81 | PTGS2 (0.37) | PTGS2TBXA2R | |
| SCHEMBL13628850 | 0.80 | PTGS2 (0.36) | PTGS2TBXA2R | |
| SCHEMBL13628824 | 0.80 | RAB9A (0.36) | PTGS2POLBTBXA2R | |
| SCHEMBL13628851 | 0.80 | PTGS2 (0.36) | PTGS2TP53TBXA2R | |
| SCHEMBL13628832 | 0.79 | TRPC5 (0.38) | PTGS2POLB | |
| SCHEMBL13628857 | 0.78 | CCR2 (0.40) | PTGS2TP53TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |