Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628859 | 0.88 | PTGS2 (0.45) | PTGS2ACLYGNRHR | |
| SCHEMBL13628846 | 0.83 | POLB (0.41) | CYP11B2GNRHRPKMNPSR1 | |
| SCHEMBL13628848 | 0.82 | PTGS2 (0.42) | PTGS2GNRHR | |
| SCHEMBL2923546 | 0.79 | PTGS2 (0.60) | CYP11B2FYNPTGS2CYP11B1ACLY | |
| SCHEMBL13628821 | 0.78 | MAPT (0.37) | PTGS2MAPTNPSR1 | |
| SCHEMBL13628832 | 0.78 | TRPC5 (0.38) | PTGS2MAPT | |
| SCHEMBL13628853 | 0.77 | PTGS2 (0.37) | PTGS2MAPTNPSR1 | |
| SCHEMBL13628824 | 0.77 | RAB9A (0.36) | PTGS2MAPT | |
| SCHEMBL13628850 | 0.77 | PTGS2 (0.36) | PTGS2MAPTNPSR1 | |
| SCHEMBL13628843 | 0.75 | AGTR1 (0.40) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |