Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628853 | 0.85 | PTGS2 (0.37) | PTGS2DRD2ALDH1A1HTTKMT2A | |
| SCHEMBL13628824 | 0.82 | RAB9A (0.36) | PTGS2ALDH1A1HTTTSHRTBXA2R | |
| SCHEMBL13628850 | 0.80 | PTGS2 (0.36) | PTGS2GRIN1GRIN2BHTTKMT2A | |
| SCHEMBL13628859 | 0.80 | PTGS2 (0.45) | PTGS2TP53TBXA2R | |
| SCHEMBL13628821 | 0.78 | MAPT (0.37) | PTGS2ALDH1A1KMT2AMEN1TP53 | |
| SCHEMBL2928583 | 0.78 | PTGS2 (0.56) | PTGS2SCARB1TBXA2R | |
| SCHEMBL13628832 | 0.78 | TRPC5 (0.38) | PTGS2ALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL13628857 | 0.77 | CCR2 (0.40) | PTGS2TP53TSHRNPSR1TBXA2R | |
| SCHEMBL13628847 | 0.77 | CYP11B2 (0.43) | PTGS2NPSR1 | |
| SCHEMBL13628860 | 0.76 | PTGS2 (0.46) | PTGS2TP53TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |