Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628843 | 0.92 | AGTR1 (0.40) | TP53POLBPTGS2 | |
| SCHEMBL13628844 | 0.91 | TP53 (0.37) | TP53POLBMAPTLMNAPTGS2 | |
| SCHEMBL2922490 | 0.83 | PTGS2 (0.54) | TP53POLBMAPTLMNAP2RX3 | |
| SCHEMBL13628857 | 0.76 | CCR2 (0.40) | TP53LMNAKDM4EPTGS2 | |
| SCHEMBL13628859 | 0.75 | PTGS2 (0.45) | TP53POLBPTGS2 | |
| SCHEMBL13628853 | 0.75 | PTGS2 (0.37) | MAPTLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL2925431 | 0.75 | PTGS2 (0.48) | POLBMAPTLMNAF10KDM4E | |
| SCHEMBL13628821 | 0.74 | MAPT (0.37) | TP53MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL13628847 | 0.74 | CYP11B2 (0.43) | MAPTPTGS2 | |
| SCHEMBL2921231 | 0.73 | PTGS2 (0.52) | TP53PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |