Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628841 | 0.92 | TP53 (0.43) | TP53POLBPTGS2 | |
| SCHEMBL13628844 | 0.91 | TP53 (0.37) | TP53TBXA2RPOLBPTGS2 | |
| SCHEMBL2921231 | 0.81 | PTGS2 (0.52) | AGTR1AGTR2TP53TBXA2RCCR2 | |
| SCHEMBL13628857 | 0.81 | CCR2 (0.40) | TP53TBXA2RCCR2PTGS2 | |
| SCHEMBL13628856 | 0.78 | CNR2 (0.40) | TP53POLB | |
| SCHEMBL13628859 | 0.76 | PTGS2 (0.45) | TP53TBXA2RPOLBPTGS2 | |
| SCHEMBL13628853 | 0.76 | PTGS2 (0.37) | TBXA2RPTGS2 | |
| SCHEMBL2922490 | 0.75 | PTGS2 (0.54) | TP53TBXA2RCCR2POLBPTGS2 | |
| SCHEMBL13628847 | 0.75 | CYP11B2 (0.43) | PTGS2 | |
| SCHEMBL13628821 | 0.75 | MAPT (0.37) | TP53TBXA2RPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |