Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628841 | 0.91 | TP53 (0.43) | TP53POLBMAPTLMNAPTGS2 | |
| SCHEMBL13628843 | 0.91 | AGTR1 (0.40) | TP53POLBPTGS2TBXA2R | |
| SCHEMBL13628856 | 0.88 | CNR2 (0.40) | TP53POLBLMNABAZ2B | |
| SCHEMBL2921311 | 0.82 | PTGS2 (0.50) | ACSS2BAZ2BPPARGPTGS2TBXA2R | |
| SCHEMBL2922490 | 0.75 | PTGS2 (0.54) | TP53POLBMAPTLMNAPTGS2 | |
| SCHEMBL13628857 | 0.75 | CCR2 (0.40) | TP53LMNAPTGS2TBXA2R | |
| SCHEMBL13628859 | 0.74 | PTGS2 (0.45) | TP53POLBPTGS2TBXA2R | |
| SCHEMBL13628853 | 0.74 | PTGS2 (0.37) | MAPTLMNAPTGS2TBXA2R | |
| SCHEMBL2924408 | 0.73 | CNR2 (0.42) | BAZ2BPTGS2 | |
| SCHEMBL13628847 | 0.73 | CYP11B2 (0.43) | MAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612070-B2 | Heterocyclic compounds as antiinflammatory agents and cyclooxygenase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-11-03 | — | — | US | disclosed |