Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.71 |
| ▸ | MAOA | P21397 | 5/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.71 |
| ▸ | ACHE | P22303 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.71 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxsalen SCHEMBL19168 | 0.83 | CYP3A4 (1.00) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| Methoxsalen SCHEMBL29376525 | 0.83 | CYP3A4 (1.00) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| Methoxsalen SCHEMBL2302069 | 0.83 | CYP3A4 (1.00) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| Methoxsalen SCHEMBL6142553 | 0.82 | CYP3A4 (0.97) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| SCHEMBL8806449 | 0.79 | CYP3A4 (0.71) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| SCHEMBL18788583 | 0.79 | CYP3A4 (0.71) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| SCHEMBL7781220 | 0.77 | CYP3A4 (0.72) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| Methoxsalen SCHEMBL9387169 | 0.77 | CYP3A4 (0.86) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| SCHEMBL9184365 | 0.77 | MAOA (0.76) | CYP3A4MAOACYP2D6CYP2A6ACHE | |
| SCHEMBL15946224 | 0.77 | CYP3A4 (0.59) | CYP3A4MAOACYP2D6CYP2A6ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695189-B2 | Chemical crosslinkers and compositions thereof | Nguyen, Mark Quang (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695189-B2 | Chemical crosslinkers and compositions thereof | Nguyen, Mark Quang (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160143937-A1 | METHODS OF USING CLEAVABLE DRUG CONJUGATES AND COMPOSITIONS THEREOF | Nguyen, Mark Quang (US) | 2016-05-26 | — | — | US | disclosed |
| US-20160129027-A1 | CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE | Nguyen, Mark Quang (US) | 2016-05-12 | — | — | US | disclosed |
| US-9295731-B2 | Cleavable drug conjugates, compositions thereof and methods of use | Nguyen, Mark Quang (US) | 2016-03-29 | — | — | US | disclosed |
| US-20140294851-A1 | CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE | Nguyen, Mark Quang (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140249319-A1 | CHEMICAL CROSSLINKERS AND COMPOSITIONS THEREOF | Nguyen, Mark Quang (US) | 2014-09-04 | — | — | US | disclosed |
| US-20090258381-A1 | Methods for Determining the Cleavability of Substrates | FORSCHUNGSZENTRUM BORSTEL (DE) | 2009-10-15 | — | — | US | disclosed |
| US-20090104633-A1 | Kit for Highly Sensitive Detection Assays | VYZKUMNY USTAV VETERINARNIHO LEKARSTVI (CZ) | 2009-04-23 | — | — | US | disclosed |
| US-20090104633-A1 | Kit for Highly Sensitive Detection Assays | VYZKUMNY USTAV VETERINARNIHO LEKARSTVI (CZ) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160129027-A1 | CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE | PAICS, FOLH1, DHFR | CYP3A4 675/4885MAOA 1095/4885CYP2D6 295/4885 |
| US-20140249319-A1 | CHEMICAL CROSSLINKERS AND COMPOSITIONS THEREOF | CBR3, ERCC5, LIG3 | CYP3A4 1525/4885MAOA 1267/4885CYP2D6 2096/4885 |
| US-20140294851-A1 | CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE | PAICS, FOLH1, DHFR | CYP3A4 675/4885MAOA 1095/4885CYP2D6 295/4885 |
| US-20160143937-A1 | METHODS OF USING CLEAVABLE DRUG CONJUGATES AND COMPOSITIONS THEREOF | SI, PAICS, FURIN | CYP3A4 369/4885MAOA 1125/4885CYP2D6 201/4885 |
| US-20090258381-A1 | Methods for Determining the Cleavability of Substrates | CTSF, ADAM17, ADAM10 | CYP3A4 283/4885MAOA 742/4885CYP2D6 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.